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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(16
): e652
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A Meta-analysis Reveals S-1-based Chemotherapy Improves the Survival of Patients
With Advanced Gastric Cancer
#MMPMID25906091
Wu FL
; Lu DC
; Ying YP
; Huang JJ
; Zhou AM
; Jiang DK
; Chen MW
; Yang X
; Zhou J
; Huang HQ
; Zeng HY
Medicine (Baltimore)
2015[Apr]; 94
(16
): e652
PMID25906091
show ga
The aim of this study was to compare the efficacy and safety of S-1-based therapy
versus non-S-1-based therapy in advanced gastric cancer (AGC) patients.Eligible
studies stratifying objective response rate (ORR), progression-free survival
(PFS), overall survival (OS), and adverse events (AEs) in AGC patients were
identified from Embase, Pubmed, Cochrane Library, and China National Knowledge
Infrastructure databases. The STATA package (version 11.0) was used to pool the
data from the eligible studies.Fifteen studies with 2973 AGC cases, of which 1497
(50.4%) received S-1-based therapy and 1476 (49.6%) received non-S-1-based
therapy, were identified in the meta-analysis. AGC patients who had received
S-1-based therapy had a higher median OS, median PFS, and ORR than those who had
received 5-fluorouracil (FU)-based therapy (OS: hazard ratio [HR] 0.89, 95%
confidence interval [CI] 0.80-0.98, P?=?0.015; PFS: HR 0.88, 95% CI 0.80-0.98,
P?=?0.016; ORR: OR 1.25, 95% CI 1.08-1.45, P?=?0.003, respectively). S-1-based
therapy had similar efficacy to capecitabine-based therapy in terms of median OS
(HR 1.14, 95% CI 0.91-1.41, P?=?0.253), median PFS (HR 1.01, 95% CI 0.82-1.25,
P?=?0.927), and ORR (OR 0.84, 95% CI 0.63-1.12, P?=?0.226). Subgroup analysis for
grade 3 to 4 toxicity showed higher incidence of neutropenia (relative risk
[RR]?=?0.827, P?=?0.006), nausea (RR?=?0.808, P?=?0.040), and lower diarrhea
(RR?=?1.716, P?=?0.012) in 5-FU-based arm, and higher diarrhea (RR?=?0.386,
P?=?0.007) in capecitabine-based arm.S-1-based chemotherapy is favorable to AGC
patients with better clinical benefit than 5-FU-based chemotherapy and with
equivalent antitumor compare with capecitabine-based therapy.
|Capecitabine
[MESH]
|China
[MESH]
|Clinical Trials as Topic
[MESH]
|Deoxycytidine/adverse effects/*analogs & derivatives/therapeutic use
[MESH]
|Disease-Free Survival
[MESH]
|Drug Combinations
[MESH]
|Female
[MESH]
|Fluorouracil/adverse effects/*analogs & derivatives/*therapeutic use
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Oxonic Acid/adverse effects/*therapeutic use
[MESH]