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2015 ; 94
(11
): e595
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Interventions for treating displaced midshaft clavicular fractures: a Bayesian
network meta-analysis of randomized controlled trials
#MMPMID25789948
Wang J
; Meng XH
; Guo ZM
; Wu YH
; Zhao JG
Medicine (Baltimore)
2015[Mar]; 94
(11
): e595
PMID25789948
show ga
Displaced midshaft clavicle fractures are frequent injuries. There are 3
treatment methods including conservative treatment, plate fixation, and
intramedullary pin fixation. However, which is the best treatment remains a topic
of debate.To establish the optimum treatment for displaced midshaft clavicular
fractures, we did a network meta-analysis to compare 3 treatments in terms of
postoperative nonunion and infection.We searched PubMed, the Cochrane Library,
and Embase for relevant randomized controlled trials (RCTs) until the end of
October 2014. Two investigators independently reviewed the abstract and full text
of eligible studies and extracted information. We used WinBUGS 1.4 (Imperial
College School of Medicine at St Mary's, London) to perform our Bayesian network
meta-analysis. We used the graphical tools in STATA12 (StataCorp, Texas) to
present the results of statistical analyses of WinBUGS14. Nonunion and infection
were presented as odd ratios (ORs) with 95% confidence intervals (CIs). We also
presented the results using surface under the cumulative ranking curve (SUCRA). A
higher SUCRA value suggests better results for respective treatment
method.Thirteen RCTs were included in our network meta-analysis, with a total of
894 patients randomized to receive 1 of 3 treatments. Nonunion rates were 0.9%,
2.4%, and 11.4% for intramedullary pin fixation, plate fixation, and conservative
method, respectively. Nonunion occurred more commonly in patients treated with
conservative method than in patients treated with either plate fixation (OR,
0.18; 95% CI, 0.05-0.46) or intramedullary pin fixation (OR, 0.12; 95% CI,
0.01-0.50). There was no significant difference between plate and intramedullary
pin fixation in nonunion (OR, 3.64; 95% CI, 0.31-17.27). Furthermore, SUCRA
probabilities were 87.8%, 62.0%, and 0.2% for intramedullary pin fixation, plate
fixation, and conservative method, respectively. Infection rates were 3.6% and
3.9% for intramedullary pin fixation and plate fixation, respectively. There was
no significant difference between plate and intramedullary pin fixation in
infection (OR, 3.64; 95% CI, 0.31-17.27). SUCRA probabilities were 46.5% and 8.5%
for intramedullary pin and plate fixation, respectively.Our network meta-analysis
suggested that intramedullary pin fixation is the optimum treatment method for
displaced midshaft clavicle fracture because of the low probabilities of nonunion
and infection.