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10.1097/MD.0000000000000034 http://scihub22266oqcxt.onion/10.1097/MD.0000000000000034 C4602453!4602453 !25181311     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25181311 &cmd=llinks): Failed to open stream: HTTP request failed! 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Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment |pdf=|usr=}}{{25181311 }} gab.com Text Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=25181311 #FOAvip Infective endocarditis is an uncommon manifestation of infection with Histoplasma capsulatum. The diagnosis is frequently missed, and outcomes historically have been poor. We present 14 cases of Histoplasma endocarditis seen in the last decade at medical centers throughout the United States. All patients were men, and 10 of the 14 had an infected prosthetic aortic valve. One patient had an infected left atrial myxoma. Symptoms were present a median of 7 weeks before the diagnosis was established. Blood cultures yielded H. capsulatum in only 6 (43%) patients. Histoplasma antigen was present in urine and/or serum in all but 3 of the patients and provided the first clue to the diagnosis of histoplasmosis for several patients. Antibody testing was positive for H. capsulatum in 6 of 8 patients in whom the test was performed. Eleven patients underwent surgery for valve replacement or myxoma removal. Large, friable vegetations were noted at surgery in most patients, confirming the preoperative transesophageal echocardiography findings. Histopathologic examination of valve tissue and the myxoma revealed granulomatous inflammation and large numbers of organisms in most specimens. Four of the excised valves and the atrial myxoma showed a mixture of both yeast and hyphal forms on histopathology. A lipid formulation of amphotericin B, administered for a median of 29 days, was the initial therapy in 11 of the 14 patients. This was followed by oral itraconazole therapy, in all but 2 patients. The length of itraconazole suppressive therapy ranged from 11 months to lifelong administration. Three patients (21%) died within 3 months of the date of diagnosis. All 3 deaths were in patients who had received either no or minimal (1 day and 1 week) amphotericin B. Twit Text FOAVip Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=25181311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25181311 #FOAvip English Wikipedia <ref>{{Cite pmid|25181311 }}</ref> Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment #MMPMID25181311 Riddell J 4th ; Kauffman CA ; Smith JA ; Assi M ; Blue S ; Buitrago MI ; Deresinski S ; Wright PW ; Drevets DA ; Norris SA ; Vikram HR ; Carson PJ ; Vergidis P ; Carpenter J ; Seidenfeld SM ; Wheat LJ Medicine (Baltimore) 2014[Jul]; 93 (5 ): 186-193 PMID25181311 show ga Infective endocarditis is an uncommon manifestation of infection with Histoplasma capsulatum. The diagnosis is frequently missed, and outcomes historically have been poor. We present 14 cases of Histoplasma endocarditis seen in the last decade at medical centers throughout the United States. All patients were men, and 10 of the 14 had an infected prosthetic aortic valve. One patient had an infected left atrial myxoma. Symptoms were present a median of 7 weeks before the diagnosis was established. Blood cultures yielded H. capsulatum in only 6 (43%) patients. Histoplasma antigen was present in urine and/or serum in all but 3 of the patients and provided the first clue to the diagnosis of histoplasmosis for several patients. Antibody testing was positive for H. capsulatum in 6 of 8 patients in whom the test was performed. Eleven patients underwent surgery for valve replacement or myxoma removal. Large, friable vegetations were noted at surgery in most patients, confirming the preoperative transesophageal echocardiography findings. Histopathologic examination of valve tissue and the myxoma revealed granulomatous inflammation and large numbers of organisms in most specimens. Four of the excised valves and the atrial myxoma showed a mixture of both yeast and hyphal forms on histopathology. A lipid formulation of amphotericin B, administered for a median of 29 days, was the initial therapy in 11 of the 14 patients. This was followed by oral itraconazole therapy, in all but 2 patients. The length of itraconazole suppressive therapy ranged from 11 months to lifelong administration. Three patients (21%) died within 3 months of the date of diagnosis. All 3 deaths were in patients who had received either no or minimal (1 day and 1 week) amphotericin B. |*Antigens, Fungal/blood/urine [MESH] |*Endocarditis/diagnosis/etiology/immunology/therapy [MESH] |*Histoplasma/drug effects/immunology [MESH] |*Histoplasmosis/complications/diagnosis/immunology/therapy [MESH] |*Myxoma/complications/pathology/surgery [MESH] |*Prosthesis-Related Infections/complications/diagnosis/microbiology/therapy [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Amphotericin B/*administration & dosage [MESH] |Antifungal Agents/administration & dosage [MESH] |Aortic Valve/pathology/surgery [MESH] |Echocardiography, Transesophageal/methods [MESH] |Heart Atria/pathology/surgery [MESH] |Heart Valve Prosthesis Implantation/adverse effects/methods [MESH] |Humans [MESH] |Itraconazole/*administration & dosage [MESH] |Male [MESH] |Medical Records, Problem-Oriented [MESH] |Middle Aged [MESH] |Treatment Outcome [MESH]Histoplasma capsulatum endocarditis: multicenter case series with revi(epmc).pdf DeepDyve Pubget Overpricing