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2015 ; 2015
(ä): 325061
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Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition,
and Behaviors in Autism: A Report of Two Cases
#MMPMID26491593
Antonucci N
; Cirillo A
; Siniscalco D
Case Rep Psychiatry
2015[]; 2015
(ä): 325061
PMID26491593
show ga
Introduction. Autism spectrum disorders are defined by behavioral and language
atypias. Growing body of evidence indicates inflammatory mediators may contribute
to the condition. Palmitoylethanolamide (PEA) is naturally occurring and has been
available as a nonprescription medical food supplement in Europe since 2008. PEA
has been tested in thousands of human subjects without any noted significant side
effects. Here we report the first cases of the administration of PEA to two
children with autism. Case Presentations. The first 13-year-old male child
(Subject 1) presented with a total IgE of 572?IU/mL (nl < 200) and with low
mature CD57(+) natural killer cell counts (32?cells/µL; nl = 60-300?cells/µL) and
with significant eczema and allergic stigmata. Expressive language, as measured
by mean length of utterance, and overall autism severity as measured by the
Childhood Autism Rating Scale, Second Edition, improved significantly. Atopic
symptoms diminished. No side effects were reported. The second male child, age 15
(Subject 2), also displayed noticeable and rapid improvements in cognitive,
behaviors, and sociability. Conclusion. Currently, there is no definitive
treatment for autism condition. Palmitoylethanolamide could be an effective
treatment for autism syndrome. We propose appropriate double-blind clinical
trials to further explore palmitoylethanolamide efficacy and safety.