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10.1097/MCG.0000000000000355

http://scihub22266oqcxt.onion/10.1097/MCG.0000000000000355
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C4602161!4602161!26447970
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suck abstract from ncbi


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pmid26447970      J+Clin+Gastroenterol 2015 ; 49 (0 1): S7-S12
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  • From birth to ?immuno-health?, allergies and enterocolitis #MMPMID26447970
  • Houghteling PD; Walker WA
  • J Clin Gastroenterol 2015[Nov]; 49 (0 1): S7-S12 PMID26447970show ga
  • Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. After birth and initial colonization, the immune system must be able to activate against pathogens, but also achieve oral tolerance of food and resident gut microbes. Through microbial signals and appropriate nutrition, the immune system is able to achieve homeostasis. Major challenges to successful colonization and immune system regulation include abnormal microbial inoculi (cesarean section, hygiene) and antibiotics. When normal colonization is interrupted, dysbiosis occurs. This imbalance of microbes and subsequently of the immune system can result in allergic diseases, asthma or necrotizing enterocolitis. Probiotics and probiotic-derived therapies represent an exciting avenue to replete the population of commensal microbes and to prevent the immune-mediated sequelae of dysbiosis.
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