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10.1083/jcb.201505007 http://scihub22266oqcxt.onion/10.1083/jcb.201505007 C4602038!4602038 !26459603     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26459603 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 211 (1 ): 173-90 Nephropedia Template TP {{tp|p=26459603 |t=2015. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction |pdf=|usr=}}{{26459603 }} gab.com Text Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26459603 #FOAvip Progressive fibrosis is characterized by excessive deposition of extracellular matrix (ECM), resulting in gross alterations in tissue mechanics. Changes in tissue mechanics can further augment scar deposition through fibroblast mechanotransduction. In idiopathic pulmonary fibrosis, a fatal form of progressive lung fibrosis, previous work has shown that loss of Thy-1 (CD90) expression in fibroblasts correlates with regions of active fibrogenesis, thus representing a pathologically relevant fibroblast subpopulation. We now show that Thy-1 is a regulator of fibroblast rigidity sensing. Thy-1 physically couples to inactive ?v?3 integrins via its RGD-like motif, altering baseline integrin avidity to ECM ligands and also facilitating preadhesion clustering of integrin and membrane rafts via Thy-1's glycophosphatidylinositol tether. Disruption of Thy-1-?v?3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired mechanosensitive, force-induced Rho signaling, and rigidity sensing. Loss of Thy-1 was sufficient to induce myofibroblast differentiation in soft ECMs and may represent a physiological mechanism important in wound healing and fibrosis. Twit Text FOAVip Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26459603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459603 #FOAvip English Wikipedia <ref>{{Cite pmid|26459603 }}</ref> Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction #MMPMID26459603 Fiore VF ; Strane PW ; Bryksin AV ; White ES ; Hagood JS ; Barker TH J Cell Biol 2015[Oct]; 211 (1 ): 173-90 PMID26459603 show ga Progressive fibrosis is characterized by excessive deposition of extracellular matrix (ECM), resulting in gross alterations in tissue mechanics. Changes in tissue mechanics can further augment scar deposition through fibroblast mechanotransduction. In idiopathic pulmonary fibrosis, a fatal form of progressive lung fibrosis, previous work has shown that loss of Thy-1 (CD90) expression in fibroblasts correlates with regions of active fibrogenesis, thus representing a pathologically relevant fibroblast subpopulation. We now show that Thy-1 is a regulator of fibroblast rigidity sensing. Thy-1 physically couples to inactive ?v?3 integrins via its RGD-like motif, altering baseline integrin avidity to ECM ligands and also facilitating preadhesion clustering of integrin and membrane rafts via Thy-1's glycophosphatidylinositol tether. Disruption of Thy-1-?v?3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired mechanosensitive, force-induced Rho signaling, and rigidity sensing. Loss of Thy-1 was sufficient to induce myofibroblast differentiation in soft ECMs and may represent a physiological mechanism important in wound healing and fibrosis. |*Mechanotransduction, Cellular [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Extracellular Matrix/physiology [MESH] |Fibroblasts/*physiology [MESH] |Focal Adhesions/metabolism [MESH] |Integrin alphaVbeta3/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Proto-Oncogene Proteins c-fyn/*metabolism [MESH] |Thy-1 Antigens/*metabolism [MESH] |rho GTP-Binding Proteins/metabolism [MESH]Conformational coupling of integrin and Thy-1 regulates Fyn priming an(epmc).pdf DeepDyve Pubget Overpricing