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10.1371/journal.pone.0138276

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suck abstract from ncbi


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pmid26457678
      PLoS+One 2015 ; 10 (10 ): e0138276
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  • A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture #MMPMID26457678
  • Jégu T ; Domenichini S ; Blein T ; Ariel F ; Christ A ; Kim SK ; Crespi M ; Boutet-Mercey S ; Mouille G ; Bourge M ; Hirt H ; Bergounioux C ; Raynaud C ; Benhamed M
  • PLoS One 2015[]; 10 (10 ): e0138276 PMID26457678 show ga
  • Chromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli. Recently, chromatin remodelers such as SWI/SNF complexes have been recognized as key regulators of chromatin architecture. To gain insight into the function of these complexes during root development, we have analyzed Arabidopsis knock-down lines for one sub-unit of SWI/SNF complexes: BAF60. Here, we show that BAF60 is a positive regulator of root development and cell cycle progression in the root meristem via its ability to down-regulate cytokinin production. By opposing both the deposition of active histone marks and the formation of a chromatin regulatory loop, BAF60 negatively regulates two crucial target genes for cytokinin biosynthesis (IPT3 and IPT7) and one cell cycle inhibitor (KRP7). Our results demonstrate that SWI/SNF complexes containing BAF60 are key factors governing the equilibrium between formation and dissociation of a chromatin loop controlling phytohormone production and cell cycle progression.
  • |*Chromatin Assembly and Disassembly [MESH]
  • |Alkyl and Aryl Transferases/metabolism [MESH]
  • |Arabidopsis Proteins/*metabolism [MESH]
  • |Arabidopsis/cytology/genetics/growth & development/metabolism [MESH]
  • |Carrier Proteins/metabolism [MESH]
  • |Cell Cycle [MESH]
  • |Cell Cycle Proteins [MESH]
  • |Chromatin/*genetics/metabolism [MESH]
  • |Chromosomal Proteins, Non-Histone/*metabolism [MESH]
  • |Cytokinins/*biosynthesis [MESH]
  • |DNA, Plant/genetics [MESH]
  • |Epigenesis, Genetic [MESH]
  • |Genetic Loci/genetics [MESH]
  • |Histones/metabolism [MESH]


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