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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(10
): e0138224
Nephropedia Template TP
gab.com Text
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English Wikipedia
SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for
Diabetic Peripheral Neuropathy
#MMPMID26457582
Selvarajah D
; Cash T
; Davies J
; Sankar A
; Rao G
; Grieg M
; Pallai S
; Gandhi R
; Wilkinson ID
; Tesfaye S
PLoS One
2015[]; 10
(10
): e0138224
PMID26457582
show ga
Clinical methods of detecting diabetic peripheral neuropathy (DPN) are not
objective and reproducible. We therefore evaluated if SUDOSCAN, a new method
developed to provide a quick, non-invasive and quantitative assessment of
sudomotor function can reliably screen for DPN. 70 subjects (45 with type 1
diabetes and 25 healthy volunteers [HV]) underwent detailed assessments including
clinical, neurophysiological and 5 standard cardiovascular reflex tests (CARTs).
Using the American Academy of Neurology criteria subjects were classified into
DPN and No-DPN groups. Based on CARTs subjects were also divided into CAN,
subclinical-CAN and no-CAN. Sudomotor function was assessed with measurement of
hand and foot Electrochemical Skin Conductance (ESC) and calculation of the CAN
risk score. Foot ESC (?S) was significantly lower in subjects with DPN [n = 24;
53.5(25.1)] compared to the No-DPN [77.0(7.9)] and HV [77.1(14.3)] groups (ANCOVA
p<0.001). Sensitivity and specificity of foot ESC for classifying DPN were 87.5%
and 76.2%, respectively. The area under the ROC curve (AUC) was 0.85. Subjects
with CAN had significantly lower foot [55.0(28.2)] and hand [53.5(19.6)] ESC
compared to No-CAN [foot ESC, 72.1(12.2); hand ESC 64.9(14.4)] and HV groups
(ANCOVA p<0.001 and 0.001, respectively). ROC analysis of CAN risk score to
correctly classify CAN revealed a sensitivity of 65.0% and specificity of 80.0%.
AUC was 0.75. Both foot and hand ESC demonstrated strong correlation with
individual parameters and composite scores of nerve conduction and CAN. SUDOSCAN,
a non-invasive and quick test, could be used as an objective screening test for
DPN in busy diabetic clinics, insuring adherence to current recommendation of
annual assessments for all diabetic patients that remains unfulfilled.
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