Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4161/21541248.2014.989792 http://scihub22266oqcxt.onion/10.4161/21541248.2014.989792 C4601481!4601481!25862162     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2015 ; 6 (1): 16-9 Nephropedia Template TP {{tp|p=25862162|t=2015. Rho GEFs and GAPs: Emerging integrators of extracellular matrix signaling |pdf=|usr=}}{{25862162}} gab.com Text Rho GEFs and GAPs: Emerging integrators of extracellular matrix signaling JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25862162 #FOAvip Investigating cell migration in 3D settings has revealed that specific extracellular matrix environments require differential activities of the Rho GTPases for efficient migration. However, it is largely unknown how the activities of specific Rho GTPases are modulated to direct cell migration in response to different extracellular matrix cues. We have recently reported that extracellular matrix-dependent regulation of a specific Rho GEF is a fundamental mechanism governing cell migration in different microenvironments, providing a direct mechanism for extracellular matrix-specific regulation of Rho GTPase activity directing cell motility. We discovered that the Rho GEF ?Pix has a unique function during cell migration in fibrillar collagen environments by restraining RhoA signaling through a conserved signaling axis involving Cdc42 and the Rho GAP srGAP1. In this Commentary, we expand upon this new pathway and discuss potential mechanotransductive and therapeutic applications. Additionally, we speculate on a generalized role for Rho GEFs and GAPs in providing localized, context-dependent responses to the cellular microenvironment during cell migration and other cellular processes. Twit Text FOAVip Rho GEFs and GAPs: Emerging integrators of extracellular matrix signaling ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25862162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25862162 #FOAvip English Wikipedia <ref>{{Cite pmid|25862162}}</ref> Rho GEFs and GAPs: Emerging integrators of extracellular matrix signaling #MMPMID25862162 Kutys ML; Yamada KM Small GTPases 2015[Jan]; 6 (1): 16-9 PMID25862162show ga Investigating cell migration in 3D settings has revealed that specific extracellular matrix environments require differential activities of the Rho GTPases for efficient migration. However, it is largely unknown how the activities of specific Rho GTPases are modulated to direct cell migration in response to different extracellular matrix cues. We have recently reported that extracellular matrix-dependent regulation of a specific Rho GEF is a fundamental mechanism governing cell migration in different microenvironments, providing a direct mechanism for extracellular matrix-specific regulation of Rho GTPase activity directing cell motility. We discovered that the Rho GEF ?Pix has a unique function during cell migration in fibrillar collagen environments by restraining RhoA signaling through a conserved signaling axis involving Cdc42 and the Rho GAP srGAP1. In this Commentary, we expand upon this new pathway and discuss potential mechanotransductive and therapeutic applications. Additionally, we speculate on a generalized role for Rho GEFs and GAPs in providing localized, context-dependent responses to the cellular microenvironment during cell migration and other cellular processes. äRho GEFs and GAPs: Emerging integrators of extracellular matrix signal(epmc).pdf DeepDyve Pubget Overpricing