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10.4161/21541248.2014.975002 http://scihub22266oqcxt.onion/10.4161/21541248.2014.975002 C4601187!4601187!25425145     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2014 ; 5 (3): ä Nephropedia Template TP {{tp|p=25425145|t=2014. ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions |pdf=|usr=}}{{25425145}} gab.com Text ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25425145 #FOAvip The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbation of this balance can result in dysregulated blood vessel morphogenesis and drive pathologies including cancer. Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro-angiogenic signaling and promoting vascular stability. Loss of ARHGAP18 promotes EC hypersprouting during zebrafish and murine retinal vessel development and enhances tumor vascularization and growth. Endogenous ARHGAP18 acts specifically on RhoC and relocalizes to the angiogenic and destabilized EC junctions in a ROCK dependent manner, where it is important in reaffirming stable EC junctions and suppressing tip cell behavior, at least partially through regulation of tip cell genes, Dll4, Flk-1 and Flt-4. These findings highlight ARHGAP18 as a specific RhoGAP to fine tune vascular morphogenesis, limiting tip cell formation and promoting junctional integrity to stabilize the angiogenic architecture. Twit Text FOAVip ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25425145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25425145 #FOAvip English Wikipedia <ref>{{Cite pmid|25425145}}</ref> ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions #MMPMID25425145 Chang GH; Lay AJ; Ting KK; Zhao Y; Coleman PR; Powter EE; Formaz-Preston A; Jolly CJ; Bower NI; Hogan BM; Rinkwitz S; Becker TS; Vadas MA; Gamble JR Small GTPases 2014[]; 5 (3): ä PMID25425145show ga The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbation of this balance can result in dysregulated blood vessel morphogenesis and drive pathologies including cancer. Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro-angiogenic signaling and promoting vascular stability. Loss of ARHGAP18 promotes EC hypersprouting during zebrafish and murine retinal vessel development and enhances tumor vascularization and growth. Endogenous ARHGAP18 acts specifically on RhoC and relocalizes to the angiogenic and destabilized EC junctions in a ROCK dependent manner, where it is important in reaffirming stable EC junctions and suppressing tip cell behavior, at least partially through regulation of tip cell genes, Dll4, Flk-1 and Flt-4. These findings highlight ARHGAP18 as a specific RhoGAP to fine tune vascular morphogenesis, limiting tip cell formation and promoting junctional integrity to stabilize the angiogenic architecture. äARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip format(epmc).pdf DeepDyve Pubget Overpricing