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10.1155/2015/791926

http://scihub22266oqcxt.onion/10.1155/2015/791926
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suck abstract from ncbi


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pmid26491688      Biomed+Res+Int 2015 ; 2015 (ä): ä
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  • Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction #MMPMID26491688
  • Choi JW; Fujii T; Fujii N
  • Biomed Res Int 2015[]; 2015 (ä): ä PMID26491688show ga
  • The aim of this study was to assess the significance of the neutrophil gelatinase-associated lipocalin/serum creatinine ratio (NGAL/sCr ratio) in patients with renal dysfunction. The percent difference between plasma NGAL level and the NGAL/sCr ratio was 36.7% (95% CI, 18.4?83.7%) in patients with sCr level ? 1.2?mg/dL. In a multivariate analysis, high sensitivity C-reactive protein (hsCRP) was significantly associated with the NGAL/sCr ratio and plasma NGAL level (r = 0.526 and r = 0.453, resp., P < 0.001). In a receiver operating characteristics curve, the diagnostic ability of the NGAL/sCr ratio to identify hsCRP > 4.0?mg/dL was superior to that of NGAL [0.783 (95% CI, 0.674?0.892) versus 0.733 (95% CI, 0.615?0.852), P = 0.032]. The area under the curve of the NGAL/sCr ratio was larger than that of hsCRP to detect corrected erythrocyte sedimentation rate > 25?mm/h and the neutrophil-to-lymphocyte ratio >4.5 in renal dysfunction. In short, the NGAL/sCr ratio may offer useful information when screening patients with both systemic inflammation and renal dysfunction.
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