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10.1038/ncomms9437 http://scihub22266oqcxt.onion/10.1038/ncomms9437 C4600741!4600741!26436530     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26436530|t=2015. Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation |pdf=|usr=}}{{26436530}} gab.com Text Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26436530 #FOAvip Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4+ T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes+ CD4+ T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes+ CD4+ T cells. Twit Text FOAVip Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26436530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26436530 #FOAvip English Wikipedia <ref>{{Cite pmid|26436530}}</ref> Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation #MMPMID26436530 Raveney BJE; Oki S; Hohjoh H; Nakamura M; Sato W; Murata M; Yamamura T Nat Commun 2015[]; 6 (ä): ä PMID26436530show ga Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4+ T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes+ CD4+ T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes+ CD4+ T cells. äEomesodermin-expressing T-helper cells are essential for chronic neuro(epmc).pdf DeepDyve Pubget Overpricing