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10.1155/2015/146282 http://scihub22266oqcxt.onion/10.1155/2015/146282 C4600505!4600505!26491220     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26491220|t=2015. Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |pdf=|usr=}}{{26491220}} gab.com Text Targeting the Mitotic Catastrophe Signaling Pathway in Cancer JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26491220 #FOAvip Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy. Twit Text FOAVip Targeting the Mitotic Catastrophe Signaling Pathway in Cancer ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26491220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26491220 #FOAvip English Wikipedia <ref>{{Cite pmid|26491220}}</ref> Targeting the Mitotic Catastrophe Signaling Pathway in Cancer #MMPMID26491220 Mc Gee MM Mediators Inflamm 2015[]; 2015 (ä): ä PMID26491220show ga Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy. äTargeting the Mitotic Catastrophe Signaling Pathway in Cancer (epmc).pdf DeepDyve Pubget Overpricing