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10.1371/journal.ppat.1005193 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005193 C4599894!4599894!26452143     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2015 ; 11 (10): ä Nephropedia Template TP {{tp|p=26452143|t=2015. IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection |pdf=|usr=}}{{26452143}} gab.com Text IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26452143 #FOAvip Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL?4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-? and TNF-? with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection. Twit Text FOAVip IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26452143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26452143 #FOAvip English Wikipedia <ref>{{Cite pmid|26452143}}</ref> IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection #MMPMID26452143 Lee A; Park SP; Park CH; Kang BH; Park SH; Ha SJ; Jung KC PLoS Pathog 2015[Oct]; 11 (10): ä PMID26452143show ga Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL?4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-? and TNF-? with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection. äIL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection (epmc).pdf DeepDyve Pubget Overpricing