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10.1161/JAHA.115.002096

http://scihub22266oqcxt.onion/10.1161/JAHA.115.002096
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suck abstract from ncbi


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pmid26391132
      J+Am+Heart+Assoc 2015 ; 4 (9 ): e002096
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  • Causes of Death Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis #MMPMID26391132
  • Xiong TY ; Liao YB ; Zhao ZG ; Xu YN ; Wei X ; Zuo ZL ; Li YJ ; Cao JY ; Tang H ; Jilaihawi H ; Feng Y ; Chen M
  • J Am Heart Assoc 2015[Sep]; 4 (9 ): e002096 PMID26391132 show ga
  • BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an effective alternative to surgical aortic valve replacement in patients at high surgical risk. However, there is little published literature on the exact causes of death. METHODS AND RESULTS: The PubMed database was systematically searched for studies reporting causes of death within and after 30 days following TAVR. Twenty-eight studies out of 3934 results retrieved were identified. In the overall analysis, 46.4% and 51.6% of deaths were related to noncardiovascular causes within and after the first 30 days, respectively. Within 30 days of TAVR, infection/sepsis (18.5%), heart failure (14.7%), and multiorgan failure (13.2%) were the top 3 causes of death. Beyond 30 days, infection/sepsis (14.3%), heart failure (14.1%), and sudden death (10.8%) were the most common causes. All possible subgroup analyses were made. No significant differences were seen for proportions of cardiovascular deaths except the comparison between moderate (mean STS score 4 to 8) and high (mean STS score >8) -risk patients after 30 days post-TAVR (56.0% versus 33.5%, P=0.005). CONCLUSIONS: Cardiovascular and noncardiovascular causes of death are evenly balanced both in the perioperative period and at long-term follow-up after TAVR. Infection/sepsis and heart failure were the most frequent noncardiovascular and cardiovascular causes of death. This study highlights important areas of clinical focus that could further improve outcomes after TAVR.
  • |*Death, Sudden/etiology [MESH]
  • |Aortic Valve Stenosis/diagnosis/mortality/*therapy [MESH]
  • |Cardiac Catheterization/adverse effects/instrumentation/*mortality [MESH]
  • |Cause of Death [MESH]
  • |Chi-Square Distribution [MESH]
  • |Heart Failure/diagnosis/etiology/*mortality [MESH]
  • |Heart Valve Prosthesis [MESH]
  • |Heart Valve Prosthesis Implantation/adverse effects/instrumentation/*mortality [MESH]
  • |Humans [MESH]
  • |Multiple Organ Failure/diagnosis/etiology/*mortality [MESH]
  • |Prosthesis Design [MESH]
  • |Risk Assessment [MESH]
  • |Risk Factors [MESH]
  • |Sepsis/diagnosis/etiology/*mortality [MESH]
  • |Time Factors [MESH]


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