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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Am+Heart+Assoc
2015 ; 4
(9
): e002096
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Causes of Death Following Transcatheter Aortic Valve Replacement: A Systematic
Review and Meta-Analysis
#MMPMID26391132
Xiong TY
; Liao YB
; Zhao ZG
; Xu YN
; Wei X
; Zuo ZL
; Li YJ
; Cao JY
; Tang H
; Jilaihawi H
; Feng Y
; Chen M
J Am Heart Assoc
2015[Sep]; 4
(9
): e002096
PMID26391132
show ga
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an effective
alternative to surgical aortic valve replacement in patients at high surgical
risk. However, there is little published literature on the exact causes of death.
METHODS AND RESULTS: The PubMed database was systematically searched for studies
reporting causes of death within and after 30 days following TAVR. Twenty-eight
studies out of 3934 results retrieved were identified. In the overall analysis,
46.4% and 51.6% of deaths were related to noncardiovascular causes within and
after the first 30 days, respectively. Within 30 days of TAVR, infection/sepsis
(18.5%), heart failure (14.7%), and multiorgan failure (13.2%) were the top 3
causes of death. Beyond 30 days, infection/sepsis (14.3%), heart failure (14.1%),
and sudden death (10.8%) were the most common causes. All possible subgroup
analyses were made. No significant differences were seen for proportions of
cardiovascular deaths except the comparison between moderate (mean STS score 4 to
8) and high (mean STS score >8) -risk patients after 30 days post-TAVR (56.0%
versus 33.5%, P=0.005). CONCLUSIONS: Cardiovascular and noncardiovascular causes
of death are evenly balanced both in the perioperative period and at long-term
follow-up after TAVR. Infection/sepsis and heart failure were the most frequent
noncardiovascular and cardiovascular causes of death. This study highlights
important areas of clinical focus that could further improve outcomes after TAVR.