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10.18632/oncotarget.4117 http://scihub22266oqcxt.onion/10.18632/oncotarget.4117 C4599290!4599290 !26030000     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26030000 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (18 ): 16573-87 Nephropedia Template TP {{tp|p=26030000 |t=2015. Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs) |pdf=|usr=}}{{26030000 }} gab.com Text Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs) JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26030000 #FOAvip MicroRNAs (miRNAs) are small non coding RNA molecules that play a crucial role in several pathophysiological conditions, including cancer. The stimulation of hormone-sensitive tumors by estrogens are mediated by estrogen receptor (ER)? and G protein estrogen receptor (GPER). Previous studies have reported that ER? regulates miRNA expression, while this ability of GPER remains to be elucidated. Here, we demonstrate that in SkBr3 breast cancer and HepG2 hepatocarcinoma cells, 17?-estradiol (E2) and the selective GPER ligand G-1 induce miR144 expression through GPER and the involvement of the PI3K/ERK1/2/Elk1 transduction pathway. Moreover, we show that E2 and G-1 down-regulate through miR144 the onco-suppressor Runx1 and increase cell cycle progression. The capability of E2 and G-1 in triggering the induction of miR144 and the down-regulation of Runx1 was also confirmed in cancer-associated fibroblasts (CAFs) that are main components of the tumor microenvironment driving cancer progression. Further confirming these results, Runx1 protein levels were found decreased in tumor xenografts upon G-1 treatment. On the basis of our findings miR144 and Runx1 may be included among the oncotargets of GPER action. Moreover, the present data provide new insights regarding the ability of estrogens to trigger the GPER/miR144/Runx1 transduction pathway toward the stimulation of cancer progression. Twit Text FOAVip Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs) ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26030000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26030000 #FOAvip English Wikipedia <ref>{{Cite pmid|26030000 }}</ref> Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs) #MMPMID26030000 Vivacqua A ; De Marco P ; Santolla MF ; Cirillo F ; Pellegrino M ; Panno ML ; Abonante S ; Maggiolini M Oncotarget 2015[Jun]; 6 (18 ): 16573-87 PMID26030000 show ga MicroRNAs (miRNAs) are small non coding RNA molecules that play a crucial role in several pathophysiological conditions, including cancer. The stimulation of hormone-sensitive tumors by estrogens are mediated by estrogen receptor (ER)? and G protein estrogen receptor (GPER). Previous studies have reported that ER? regulates miRNA expression, while this ability of GPER remains to be elucidated. Here, we demonstrate that in SkBr3 breast cancer and HepG2 hepatocarcinoma cells, 17?-estradiol (E2) and the selective GPER ligand G-1 induce miR144 expression through GPER and the involvement of the PI3K/ERK1/2/Elk1 transduction pathway. Moreover, we show that E2 and G-1 down-regulate through miR144 the onco-suppressor Runx1 and increase cell cycle progression. The capability of E2 and G-1 in triggering the induction of miR144 and the down-regulation of Runx1 was also confirmed in cancer-associated fibroblasts (CAFs) that are main components of the tumor microenvironment driving cancer progression. Further confirming these results, Runx1 protein levels were found decreased in tumor xenografts upon G-1 treatment. On the basis of our findings miR144 and Runx1 may be included among the oncotargets of GPER action. Moreover, the present data provide new insights regarding the ability of estrogens to trigger the GPER/miR144/Runx1 transduction pathway toward the stimulation of cancer progression. |Animals [MESH] |Cell Line, Tumor [MESH] |Core Binding Factor Alpha 2 Subunit/biosynthesis [MESH] |Estradiol/*metabolism [MESH] |Estrogen Receptor alpha/*metabolism [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Female [MESH] |Fibroblasts/pathology [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Hep G2 Cells [MESH] |Heterografts [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/biosynthesis/*genetics [MESH] |Neoplasm Transplantation [MESH] |Neoplasms/genetics/*pathology [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Receptors, Estrogen/*metabolism [MESH] |Receptors, G-Protein-Coupled/*metabolism [MESH] |Signal Transduction/genetics [MESH] |Tumor Microenvironment/physiology [MESH]Estrogenic gper signaling regulates mir144 expression in cancer cells (epmc).pdf DeepDyve Pubget Overpricing