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10.18632/oncotarget.3867 http://scihub22266oqcxt.onion/10.18632/oncotarget.3867 C4599259!4599259 !25965830     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25965830 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (18 ): 16106-19 Nephropedia Template TP {{tp|p=25965830 |t=2015. Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein ? in hepatocellular carcinomas |pdf=|usr=}}{{25965830 }} gab.com Text Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein in hepatocellular carcinomas JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25965830 #FOAvip Cancer metastasis is a complex process, and the incidence of metastasis is influenced by many biological factors. Orosomucoid 2 (ORM2) is an important glycoprotein that is mainly biosynthesized and secreted by hepatocytes. As an acute-phase protein, ORM2 likely plays important roles in anti-inflammation, immunomodulation and drug delivery. However, little is known regarding the function of ORM2 in hepatocellular carcinoma (HCC). In this study, we determined that ORM2 expression in HCC tissues was negatively associated with intrahepatic metastasis and histological grade. Moreover, the ectopic overexpression of ORM2 decreased HCC cell migration and invasion in vitro and intrahepatic metastasis in vivo, whereas silencing ORM2 expression resulted in increased tumor cell migration and invasion in vitro. The CCAAT/enhancer binding protein ? (C/EBP?) upregulated ORM2 expression, while only the LAP1/2 (C/EBP? isoforms) possessed transcription-promoting activity on the ORM2 promoter. Subsequently, we found that LAP1 repressed HCC cell migration and invasion via the induction of ORM2 expression. Consistently, the protein expression of C/EBP? was negatively associated with histological grade and positively correlated with ORM2 protein expression in HCC tissues. Collectively, our findings indicate that ORM2 is a functional downstream target of C/EBP? and functions as a tumor suppressor in HCC. Twit Text FOAVip Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein in hepatocellular carcinomas ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25965830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25965830 #FOAvip English Wikipedia <ref>{{Cite pmid|25965830 }}</ref> Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein ? in hepatocellular carcinomas #MMPMID25965830 Fang T ; Cui M ; Sun J ; Ge C ; Zhao F ; Zhang L ; Tian H ; Zhang L ; Chen T ; Jiang G ; Xie H ; Cui Y ; Yao M ; Li H ; Li J Oncotarget 2015[Jun]; 6 (18 ): 16106-19 PMID25965830 show ga Cancer metastasis is a complex process, and the incidence of metastasis is influenced by many biological factors. Orosomucoid 2 (ORM2) is an important glycoprotein that is mainly biosynthesized and secreted by hepatocytes. As an acute-phase protein, ORM2 likely plays important roles in anti-inflammation, immunomodulation and drug delivery. However, little is known regarding the function of ORM2 in hepatocellular carcinoma (HCC). In this study, we determined that ORM2 expression in HCC tissues was negatively associated with intrahepatic metastasis and histological grade. Moreover, the ectopic overexpression of ORM2 decreased HCC cell migration and invasion in vitro and intrahepatic metastasis in vivo, whereas silencing ORM2 expression resulted in increased tumor cell migration and invasion in vitro. The CCAAT/enhancer binding protein ? (C/EBP?) upregulated ORM2 expression, while only the LAP1/2 (C/EBP? isoforms) possessed transcription-promoting activity on the ORM2 promoter. Subsequently, we found that LAP1 repressed HCC cell migration and invasion via the induction of ORM2 expression. Consistently, the protein expression of C/EBP? was negatively associated with histological grade and positively correlated with ORM2 protein expression in HCC tissues. Collectively, our findings indicate that ORM2 is a functional downstream target of C/EBP? and functions as a tumor suppressor in HCC. |Animals [MESH] |Apoptosis [MESH] |Blotting, Western [MESH] |CCAAT-Enhancer-Binding Protein-beta/genetics/*metabolism [MESH] |Carcinoma, Hepatocellular/genetics/metabolism/*pathology [MESH] |Case-Control Studies [MESH] |Cell Cycle [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Chromatin Immunoprecipitation [MESH] |Female [MESH] |Follow-Up Studies [MESH] |HSC70 Heat-Shock Proteins/genetics/metabolism [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |Liver Neoplasms/genetics/metabolism/*secondary [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Staging [MESH] |Orosomucoid/genetics/*metabolism [MESH] |Prognosis [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Tumor Cells, Cultured [MESH]Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/en(epmc).pdf DeepDyve Pubget Overpricing