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10.1074/jbc.M115.668707 http://scihub22266oqcxt.onion/10.1074/jbc.M115.668707 C4598988!4598988 !26294767     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26294767 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP |pdf=|usr=}}{{26294767 }} gab.com Text The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26294767 #FOAvip Evidence suggests that the plasma membrane Ca(2+)-ATPase (PMCA), which is critical for maintaining a low intracellular Ca(2+) concentration ([Ca(2+)]i), utilizes glycolytically derived ATP in pancreatic ductal adenocarcinoma (PDAC) and that inhibition of glycolysis in PDAC cell lines results in ATP depletion, PMCA inhibition, and an irreversible [Ca(2+)]i overload. We explored whether this is a specific weakness of highly glycolytic PDAC by shifting PDAC cell (MIA PaCa-2 and PANC-1) metabolism from a highly glycolytic phenotype toward mitochondrial metabolism and assessing the effects of mitochondrial versus glycolytic inhibitors on ATP depletion, PMCA inhibition, and [Ca(2+)]i overload. The highly glycolytic phenotype of these cells was first reversed by depriving MIA PaCa-2 and PANC-1 cells of glucose and supplementing with ?-ketoisocaproate or galactose. These culture conditions resulted in a significant decrease in both glycolytic flux and proliferation rate, and conferred resistance to ATP depletion by glycolytic inhibition while sensitizing cells to mitochondrial inhibition. Moreover, in direct contrast to cells exhibiting a high glycolytic rate, glycolytic inhibition had no effect on PMCA activity and resting [Ca(2+)]i in ?-ketoisocaproate- and galactose-cultured cells, suggesting that the glycolytic dependence of the PMCA is a specific vulnerability of PDAC cells exhibiting the Warburg phenotype. Twit Text FOAVip The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26294767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26294767 #FOAvip English Wikipedia <ref>{{Cite pmid|26294767 }}</ref> The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP #MMPMID26294767 James AD ; Patel W ; Butt Z ; Adiamah M ; Dakhel R ; Latif A ; Uggenti C ; Swanton E ; Imamura H ; Siriwardena AK ; Bruce JI J Biol Chem 2015[Oct]; 290 (41 ): 24760-71 PMID26294767 show ga Evidence suggests that the plasma membrane Ca(2+)-ATPase (PMCA), which is critical for maintaining a low intracellular Ca(2+) concentration ([Ca(2+)]i), utilizes glycolytically derived ATP in pancreatic ductal adenocarcinoma (PDAC) and that inhibition of glycolysis in PDAC cell lines results in ATP depletion, PMCA inhibition, and an irreversible [Ca(2+)]i overload. We explored whether this is a specific weakness of highly glycolytic PDAC by shifting PDAC cell (MIA PaCa-2 and PANC-1) metabolism from a highly glycolytic phenotype toward mitochondrial metabolism and assessing the effects of mitochondrial versus glycolytic inhibitors on ATP depletion, PMCA inhibition, and [Ca(2+)]i overload. The highly glycolytic phenotype of these cells was first reversed by depriving MIA PaCa-2 and PANC-1 cells of glucose and supplementing with ?-ketoisocaproate or galactose. These culture conditions resulted in a significant decrease in both glycolytic flux and proliferation rate, and conferred resistance to ATP depletion by glycolytic inhibition while sensitizing cells to mitochondrial inhibition. Moreover, in direct contrast to cells exhibiting a high glycolytic rate, glycolytic inhibition had no effect on PMCA activity and resting [Ca(2+)]i in ?-ketoisocaproate- and galactose-cultured cells, suggesting that the glycolytic dependence of the PMCA is a specific vulnerability of PDAC cells exhibiting the Warburg phenotype. |*Glycolysis/drug effects [MESH] |Adenocarcinoma/pathology [MESH] |Adenosine Triphosphate/*metabolism [MESH] |Calcium/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/drug effects/*enzymology [MESH] |Cytosol/drug effects/metabolism [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Galactose/pharmacology [MESH] |Humans [MESH] |Iodoacetic Acid/pharmacology [MESH] |Keto Acids/pharmacology [MESH] |Mitochondria/drug effects/metabolism [MESH] |Pancreatic Neoplasms/*pathology [MESH]The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting(epmc).pdf DeepDyve Pubget Overpricing