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10.3390/biom5032140 http://scihub22266oqcxt.onion/10.3390/biom5032140 C4598792!4598792!26393662     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2015 ; 5 (3): 2140-59 Nephropedia Template TP {{tp|p=26393662|t=2015. The Altered Hepatic Tubulin Code in Alcoholic Liver Disease |pdf=|usr=}}{{26393662}} gab.com Text The Altered Hepatic Tubulin Code in Alcoholic Liver Disease JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26393662 #FOAvip The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively examined for decades. Because the hepatic microtubule cytoskeleton supports innumerable cellular processes, it has been the focus of many such mechanistic studies. It has long been appreciated that ?-tubulin is a major target for modification by highly reactive ethanol metabolites and reactive oxygen species. It is also now apparent that alcohol exposure induces post-translational modifications that are part of the natural repertoire, mainly acetylation. In this review, the modifications of the ?tubulin code? are described as well as those adducts by ethanol metabolites. The potential cellular consequences of microtubule modification are described with a focus on alcohol-induced defects in protein trafficking and enhanced steatosis. Possible mechanisms that can explain hepatic dysfunction are described and how this relates to the onset of liver injury is discussed. Finally, we propose that agents that alter the cellular acetylation state may represent a novel therapeutic strategy for treating liver disease. Twit Text FOAVip The Altered Hepatic Tubulin Code in Alcoholic Liver Disease ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26393662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26393662 #FOAvip English Wikipedia <ref>{{Cite pmid|26393662}}</ref> The Altered Hepatic Tubulin Code in Alcoholic Liver Disease #MMPMID26393662 Groebner JL; Tuma PL Biomolecules 2015[Sep]; 5 (3): 2140-59 PMID26393662show ga The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively examined for decades. Because the hepatic microtubule cytoskeleton supports innumerable cellular processes, it has been the focus of many such mechanistic studies. It has long been appreciated that ?-tubulin is a major target for modification by highly reactive ethanol metabolites and reactive oxygen species. It is also now apparent that alcohol exposure induces post-translational modifications that are part of the natural repertoire, mainly acetylation. In this review, the modifications of the ?tubulin code? are described as well as those adducts by ethanol metabolites. The potential cellular consequences of microtubule modification are described with a focus on alcohol-induced defects in protein trafficking and enhanced steatosis. Possible mechanisms that can explain hepatic dysfunction are described and how this relates to the onset of liver injury is discussed. Finally, we propose that agents that alter the cellular acetylation state may represent a novel therapeutic strategy for treating liver disease. äThe Altered Hepatic Tubulin Code in Alcoholic Liver Disease (epmc).pdf DeepDyve Pubget Overpricing