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10.3390/biom5031652 http://scihub22266oqcxt.onion/10.3390/biom5031652 C4598769!4598769!26287259     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2015 ; 5 (3): 1652-70 Nephropedia Template TP {{tp|p=26287259|t=2015. Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy |pdf=|usr=}}{{26287259}} gab.com Text Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26287259 #FOAvip Most chemotherapy regimens contain at least one DNA-damaging agent that preferentially affects the growth of cancer cells. This strategy takes advantage of the differences in cell proliferation between normal and cancer cells. Chemotherapeutic drugs are usually designed to target rapid-dividing cells because sustained proliferation is a common feature of cancer [1,2]. Rapid DNA replication is essential for highly proliferative cells, thus blocking of DNA replication will create numerous mutations and/or chromosome rearrangements?ultimately triggering cell death [3]. Along these lines, DNA topoisomerase inhibitors are of great interest because they help to maintain strand breaks generated by topoisomerases during replication. In this article, we discuss the characteristics of topoisomerase (DNA) I (TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy. Twit Text FOAVip Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26287259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26287259 #FOAvip English Wikipedia <ref>{{Cite pmid|26287259}}</ref> Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy #MMPMID26287259 Xu Y; Her C Biomolecules 2015[Sep]; 5 (3): 1652-70 PMID26287259show ga Most chemotherapy regimens contain at least one DNA-damaging agent that preferentially affects the growth of cancer cells. This strategy takes advantage of the differences in cell proliferation between normal and cancer cells. Chemotherapeutic drugs are usually designed to target rapid-dividing cells because sustained proliferation is a common feature of cancer [1,2]. Rapid DNA replication is essential for highly proliferative cells, thus blocking of DNA replication will create numerous mutations and/or chromosome rearrangements?ultimately triggering cell death [3]. Along these lines, DNA topoisomerase inhibitors are of great interest because they help to maintain strand breaks generated by topoisomerases during replication. In this article, we discuss the characteristics of topoisomerase (DNA) I (TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy. äInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anti(epmc).pdf DeepDyve Pubget Overpricing