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10.3390/biom5031515 http://scihub22266oqcxt.onion/10.3390/biom5031515 C4598762!4598762 !26193331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26193331 &cmd=llinks): Failed to open stream: HTTP request failed! 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The 3 to 5 Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease |pdf=|usr=}}{{26193331 }} gab.com Text The 3 to 5 Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26193331 #FOAvip DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species. Recently, aberrant expression of DIS3 has been found to be implicated in a range of different cancers. Perhaps most striking is the finding that DIS3 is recurrently mutated in 11% of multiple myeloma patients. Much work has been done to elucidate the structural and biochemical characteristics of DIS3, including the mechanistic details of its role as an effector of RNA decay pathways. Nevertheless, we do not understand how DIS3 mutations can lead to cancer. There are a number of studies that pertain to the function of DIS3 at the organismal level. Mutant phenotypes in S. pombe, S. cerevisiae and Drosophila suggest DIS3 homologues have a common role in cell-cycle progression and microtubule assembly. DIS3 has also recently been implicated in antibody diversification of mouse B-cells. This article aims to review current knowledge of the structure, mechanisms and functions of DIS3 as well as highlighting the genetic patterns observed within myeloma patients, in order to yield insight into the putative role of DIS3 mutations in oncogenesis. Twit Text FOAVip The 3 to 5 Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26193331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26193331 #FOAvip English Wikipedia <ref>{{Cite pmid|26193331 }}</ref> The 3 to 5 Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease #MMPMID26193331 Robinson SR ; Oliver AW ; Chevassut TJ ; Newbury SF Biomolecules 2015[Jul]; 5 (3 ): 1515-39 PMID26193331 show ga DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species. Recently, aberrant expression of DIS3 has been found to be implicated in a range of different cancers. Perhaps most striking is the finding that DIS3 is recurrently mutated in 11% of multiple myeloma patients. Much work has been done to elucidate the structural and biochemical characteristics of DIS3, including the mechanistic details of its role as an effector of RNA decay pathways. Nevertheless, we do not understand how DIS3 mutations can lead to cancer. There are a number of studies that pertain to the function of DIS3 at the organismal level. Mutant phenotypes in S. pombe, S. cerevisiae and Drosophila suggest DIS3 homologues have a common role in cell-cycle progression and microtubule assembly. DIS3 has also recently been implicated in antibody diversification of mouse B-cells. This article aims to review current knowledge of the structure, mechanisms and functions of DIS3 as well as highlighting the genetic patterns observed within myeloma patients, in order to yield insight into the putative role of DIS3 mutations in oncogenesis. |*Disease/genetics [MESH] |Animals [MESH] |Conserved Sequence [MESH] |Exosome Multienzyme Ribonuclease Complex/*chemistry/*metabolism [MESH] |Humans [MESH]The 3 to 5 Exoribonuclease DIS3: From Structure and Mechanisms to Bi(epmc).pdf DeepDyve Pubget Overpricing