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10.1007/s10534-012-9526-x http://scihub22266oqcxt.onion/10.1007/s10534-012-9526-x C4598647!4598647!22318508     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biometals 2012 ; 25 (4): 643-55 Nephropedia Template TP {{tp|p=22318508|t=2012. Physiologic implications of metal-ion transport by ZIP14 and ZIP8 |pdf=|usr=}}{{22318508}} gab.com Text Physiologic implications of metal-ion transport by ZIP14 and ZIP8 JO: Biometals http://www.kidney.de/pget.php?&tw=1&pmid=22318508 #FOAvip Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural components of larger molecules that are indispensable for life. The three metal ions possess similar chemical properties and have been shown to compete for uptake in a variety of tissues, suggesting that they share common transport proteins. Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium. Although knockout and transgenic mouse models are beginning to define the physiologic roles of ZIP14 and ZIP8 in the handling of zinc and cadmium, their roles in the metabolism of iron and manganese remain to be defined. Here we review similarities and differences in ZIP14 and ZIP8 in terms of structure, metal transport, tissue distribution, subcellular localization, and regulation. We also discuss potential roles of these proteins in the metabolism of zinc, iron, manganese, and cadmium as well as recent associations with human diseases. Twit Text FOAVip Physiologic implications of metal-ion transport by ZIP14 and ZIP8 ????Biometals http://www.kidney.de/pget.php?&tw=1&pmid=22318508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22318508 #FOAvip English Wikipedia <ref>{{Cite pmid|22318508}}</ref> Physiologic implications of metal-ion transport by ZIP14 and ZIP8 #MMPMID22318508 Jenkitkasemwong S; Wang CY; Mackenzie B; Knutson MD Biometals 2012[Aug]; 25 (4): 643-55 PMID22318508show ga Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural components of larger molecules that are indispensable for life. The three metal ions possess similar chemical properties and have been shown to compete for uptake in a variety of tissues, suggesting that they share common transport proteins. Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium. Although knockout and transgenic mouse models are beginning to define the physiologic roles of ZIP14 and ZIP8 in the handling of zinc and cadmium, their roles in the metabolism of iron and manganese remain to be defined. Here we review similarities and differences in ZIP14 and ZIP8 in terms of structure, metal transport, tissue distribution, subcellular localization, and regulation. We also discuss potential roles of these proteins in the metabolism of zinc, iron, manganese, and cadmium as well as recent associations with human diseases. äPhysiologic implications of metal-ion transport by ZIP14 and ZIP8 (epmc).pdf DeepDyve Pubget Overpricing