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2015 ; 6
(10
): 735-45
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gab.com Text
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English Wikipedia
Direct intercellular communications dominate the interaction between
adipose-derived MSCs and myofibroblasts against cardiac fibrosis
#MMPMID26271509
Li X
; Zhao H
; Qi C
; Zeng Y
; Xu F
; Du Y
Protein Cell
2015[Oct]; 6
(10
): 735-45
PMID26271509
show ga
The onset of cardiac fibrosis post myocardial infarction greatly impairs the
function of heart. Recent advances of cell transplantation showed great benefits
to restore myocardial function, among which the mesenchymal stem cells (MSCs) has
gained much attention. However, the underlying cellular mechanisms of MSC therapy
are still not fully understood. Although paracrine effects of MSCs on residual
cardiomyocytes have been discussed, the amelioration of fibrosis was rarely
studied as the hostile environment cannot support the survival of most cell
populations and impairs the diffusion of soluble factors. Here in order to
decipher the potential mechanism of MSC therapy for cardiac fibrosis, we
investigated the interplay between MSCs and cardiac myofibroblasts (mFBs) using
interactive co-culture method, with comparison to paracrine approaches, namely
treatment by MSC conditioned medium and gap co-culture method. Various fibrotic
features of mFBs were analyzed and the most prominent anti-fibrosis effects were
always obtained using direct co-culture that allowed cell-to-cell contacts.
Hepatocyte growth factor (HGF), a well-known anti-fibrosis factor, was
demonstrated to be a major contributor for MSCs' anti-fibrosis function.
Moreover, physical contacts and tube-like structures between MSCs and mFBs were
observed by live cell imaging and TEM which demonstrate the direct cellular
interactions.
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