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10.1371/journal.pone.0140249 http://scihub22266oqcxt.onion/10.1371/journal.pone.0140249 C4598150!4598150 !26448474     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26448474 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (10 ): e0140249 Nephropedia Template TP {{tp|p=26448474 |t=2015. Euphol from Euphorbia tirucalli Negatively Modulates TGF-? Responsiveness via TGF-? Receptor Segregation inside Membrane Rafts |pdf=|usr=}}{{26448474 }} gab.com Text Euphol from Euphorbia tirucalli Negatively Modulates TGF- Responsiveness via TGF- Receptor Segregation inside Membrane Rafts JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448474 #FOAvip Transforming growth factor-? (TGF-?) responsiveness in cultured cells can be modulated by TGF-? partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-? signaling by inducing TGF-? receptor movement into lipid-raft microdomains and degrading TGF-? receptors. Twit Text FOAVip Euphol from Euphorbia tirucalli Negatively Modulates TGF- Responsiveness via TGF- Receptor Segregation inside Membrane Rafts ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448474 #FOAvip English Wikipedia <ref>{{Cite pmid|26448474 }}</ref> Euphol from Euphorbia tirucalli Negatively Modulates TGF-? Responsiveness via TGF-? Receptor Segregation inside Membrane Rafts #MMPMID26448474 Chen CL ; Chen YP ; Lin MW ; Huang YB ; Chang FR ; Duh TH ; Wu DC ; Wu WC ; Kao YC ; Yang PH PLoS One 2015[]; 10 (10 ): e0140249 PMID26448474 show ga Transforming growth factor-? (TGF-?) responsiveness in cultured cells can be modulated by TGF-? partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-? signaling by inducing TGF-? receptor movement into lipid-raft microdomains and degrading TGF-? receptors. |Cell Line, Tumor [MESH] |Euphorbia/chemistry [MESH] |Fibronectins/genetics/metabolism [MESH] |Gene Expression [MESH] |Humans [MESH] |Lanosterol/*analogs & derivatives/pharmacology [MESH] |Membrane Microdomains/*metabolism [MESH] |Phosphorylation [MESH] |Plant Extracts/*pharmacology [MESH] |Protein Processing, Post-Translational [MESH] |Protein Transport [MESH] |Proteolysis [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH] |Stomach Neoplasms [MESH] |Transcriptional Activation [MESH]Euphol from Euphorbia tirucalli Negatively Modulates TGF-? Responsiven(epmc).pdf DeepDyve Pubget Overpricing