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10.1371/journal.pone.0139574 http://scihub22266oqcxt.onion/10.1371/journal.pone.0139574 C4598011!4598011 !26448331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26448331 &cmd=llinks): Failed to open stream: HTTP request failed! 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Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer s Disease Pathogenesis |pdf=|usr=}}{{26448331 }} gab.com Text Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer s Disease Pathogenesis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448331 #FOAvip Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting over 10% population over the age of 65 years. Clinically, AD is described by the symptom set of short term memory loss and cognitive decline, changes in mentation and behavior, and eventually long-term memory deficit as the disease progresses. On imaging studies, significant atrophy with subsequent increase in ventricular volume have been observed. Pathology on post-mortem brain specimens demonstrates the classic findings of increased beta amyloid (A?) deposition and the presence of neurofibrillary tangles (NFTs) within affected neurons. Neuroinflammation, dysregulation of blood-brain barrier transport and clearance, deposition of A? in cerebral blood vessels, vascular risk factors such as atherosclerosis and diabetes, and the presence of the apolipoprotein E4 allele have all been identified as playing possible roles in AD pathogenesis. Recent research has demonstrated the importance of the glymphatic system in the clearance of A? from the brain via the perivascular space surrounding cerebral blood vessels. Given the variety of hypotheses that have been proposed for AD pathogenesis, an interconnected, multilayer model offers a unique opportunity to combine these ideas into a single unifying model. Results of this model demonstrate the importance of vessel stiffness and heart rate in maintaining adequate clearance of A? from the brain. Twit Text FOAVip Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer s Disease Pathogenesis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448331 #FOAvip English Wikipedia <ref>{{Cite pmid|26448331 }}</ref> Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer s Disease Pathogenesis #MMPMID26448331 Kyrtsos CR ; Baras JS PLoS One 2015[]; 10 (10 ): e0139574 PMID26448331 show ga Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting over 10% population over the age of 65 years. Clinically, AD is described by the symptom set of short term memory loss and cognitive decline, changes in mentation and behavior, and eventually long-term memory deficit as the disease progresses. On imaging studies, significant atrophy with subsequent increase in ventricular volume have been observed. Pathology on post-mortem brain specimens demonstrates the classic findings of increased beta amyloid (A?) deposition and the presence of neurofibrillary tangles (NFTs) within affected neurons. Neuroinflammation, dysregulation of blood-brain barrier transport and clearance, deposition of A? in cerebral blood vessels, vascular risk factors such as atherosclerosis and diabetes, and the presence of the apolipoprotein E4 allele have all been identified as playing possible roles in AD pathogenesis. Recent research has demonstrated the importance of the glymphatic system in the clearance of A? from the brain via the perivascular space surrounding cerebral blood vessels. Given the variety of hypotheses that have been proposed for AD pathogenesis, an interconnected, multilayer model offers a unique opportunity to combine these ideas into a single unifying model. Results of this model demonstrate the importance of vessel stiffness and heart rate in maintaining adequate clearance of A? from the brain. |*Models, Biological [MESH] |Aged [MESH] |Aging [MESH] |Alleles [MESH] |Alzheimer Disease/*pathology [MESH] |Amyloid beta-Peptides/metabolism [MESH] |Apolipoprotein E4/genetics [MESH] |Blood-Brain Barrier/metabolism [MESH] |Bradycardia/physiopathology [MESH] |Brain/metabolism [MESH] |Cerebral Arteries/*physiology [MESH] |Cognitive Dysfunction/pathology [MESH] |Female [MESH] |Hippocampus/diagnostic imaging/physiology [MESH] |Humans [MESH] |Low Density Lipoprotein Receptor-Related Protein-1/metabolism [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH]Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel (epmc).pdf DeepDyve Pubget Overpricing