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10.1038/srep14871 http://scihub22266oqcxt.onion/10.1038/srep14871 C4597222!4597222 !26445893     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26445893 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 14871 Nephropedia Template TP {{tp|p=26445893 |t=2015. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells |pdf=|usr=}}{{26445893 }} gab.com Text FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26445893 #FOAvip Thymic epithelial cells (TECs) form a 3-dimentional network supporting thymocyte development and maturation. Besides epithelium and thymocytes, heterogeneous fibroblasts are essential components in maintaining thymic microenvironments. However, thymic fibroblast characteristics, development and function remain to be determined. We herein found that thymic non-hematopoietic CD45(-)FSP1(+) cells represent a unique Fibroblast specific protein 1 (FSP1)(-)fibroblast-derived cell subset. Deletion of these cells in FSP1-TK transgenic mice caused thymus atrophy due to the loss of TECs, especially mature medullary TECs (MHCII(high), CD80(+) and Aire(+)). In a cyclophosphamide-induced thymus injury and regeneration model, lack of non-hematopoietic CD45(-)FSP1(+) fibroblast subpopulation significantly delayed thymus regeneration. In fact, thymic FSP1(+) fibroblasts released more IL-6, FGF7 and FSP1 in the culture medium than their FSP1(-) counterparts. Further experiments showed that the FSP1 protein could directly enhance the proliferation and maturation of TECs in the in vitro culture systems. FSP1 knockout mice had significantly smaller thymus size and less TECs than their control. Collectively, our studies reveal that thymic CD45(-)FSP1(+) cells are a subpopulation of fibroblasts, which is crucial for the maintenance and regeneration of TECs especially medullary TECs through providing IL-6, FGF7 and FSP1. Twit Text FOAVip FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26445893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26445893 #FOAvip English Wikipedia <ref>{{Cite pmid|26445893 }}</ref> FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells #MMPMID26445893 Sun L ; Sun C ; Liang Z ; Li H ; Chen L ; Luo H ; Zhang H ; Ding P ; Sun X ; Qin Z ; Zhao Y Sci Rep 2015[Oct]; 5 (ä): 14871 PMID26445893 show ga Thymic epithelial cells (TECs) form a 3-dimentional network supporting thymocyte development and maturation. Besides epithelium and thymocytes, heterogeneous fibroblasts are essential components in maintaining thymic microenvironments. However, thymic fibroblast characteristics, development and function remain to be determined. We herein found that thymic non-hematopoietic CD45(-)FSP1(+) cells represent a unique Fibroblast specific protein 1 (FSP1)(-)fibroblast-derived cell subset. Deletion of these cells in FSP1-TK transgenic mice caused thymus atrophy due to the loss of TECs, especially mature medullary TECs (MHCII(high), CD80(+) and Aire(+)). In a cyclophosphamide-induced thymus injury and regeneration model, lack of non-hematopoietic CD45(-)FSP1(+) fibroblast subpopulation significantly delayed thymus regeneration. In fact, thymic FSP1(+) fibroblasts released more IL-6, FGF7 and FSP1 in the culture medium than their FSP1(-) counterparts. Further experiments showed that the FSP1 protein could directly enhance the proliferation and maturation of TECs in the in vitro culture systems. FSP1 knockout mice had significantly smaller thymus size and less TECs than their control. Collectively, our studies reveal that thymic CD45(-)FSP1(+) cells are a subpopulation of fibroblasts, which is crucial for the maintenance and regeneration of TECs especially medullary TECs through providing IL-6, FGF7 and FSP1. |Animals [MESH] |Animals, Newborn [MESH] |Cell Communication/physiology [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Cyclophosphamide/pharmacology [MESH] |Epithelial Cells/*cytology/drug effects/metabolism [MESH] |Female [MESH] |Fetus [MESH] |Fibroblast Growth Factor 7/genetics/metabolism [MESH] |Fibroblasts/*cytology/drug effects/metabolism [MESH] |Gene Expression [MESH] |Interleukin-6/genetics/metabolism [MESH] |Leukocyte Common Antigens/genetics/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Organ Culture Techniques [MESH] |Regeneration/*physiology [MESH] |S100 Calcium-Binding Protein A4 [MESH] |S100 Proteins/deficiency/*genetics [MESH]FSP1(+) fibroblast subpopulation is essential for the maintenance and (epmc).pdf DeepDyve Pubget Overpricing