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10.1371/journal.pone.0139811 http://scihub22266oqcxt.onion/10.1371/journal.pone.0139811 C4596877!4596877 !26444881     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26444881 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (10 ): e0139811 Nephropedia Template TP {{tp|p=26444881 |t=2015. Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences |pdf=|usr=}}{{26444881 }} gab.com Text Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26444881 #FOAvip We applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile isolates, which had been collected from hospitalized patients at 36 locations throughout Germany between 1990 and 2012, we demonstrate that C. difficile genomes have accumulated sequence variation sufficiently fast to document the pathogen's spread at a regional scale. We detected both previously described lineages of fluoroquinolone-resistant C. difficile ribotype 027, FQR1 and FQR2. Using Bayesian phylogeographic analyses, we show that fluoroquinolone-resistant C. difficile 027 was imported into Germany at least four times, that it had been widely disseminated across multiple federal states even before the first outbreak was noted in 2007, and that it has continued to spread since. Twit Text FOAVip Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26444881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26444881 #FOAvip English Wikipedia <ref>{{Cite pmid|26444881 }}</ref> Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences #MMPMID26444881 Steglich M ; Nitsche A ; von Müller L ; Herrmann M ; Kohl TA ; Niemann S ; Nübel U PLoS One 2015[]; 10 (10 ): e0139811 PMID26444881 show ga We applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile isolates, which had been collected from hospitalized patients at 36 locations throughout Germany between 1990 and 2012, we demonstrate that C. difficile genomes have accumulated sequence variation sufficiently fast to document the pathogen's spread at a regional scale. We detected both previously described lineages of fluoroquinolone-resistant C. difficile ribotype 027, FQR1 and FQR2. Using Bayesian phylogeographic analyses, we show that fluoroquinolone-resistant C. difficile 027 was imported into Germany at least four times, that it had been widely disseminated across multiple federal states even before the first outbreak was noted in 2007, and that it has continued to spread since. |Anti-Bacterial Agents/therapeutic use [MESH] |Bacterial Proteins/genetics [MESH] |Bayes Theorem [MESH] |Clostridioides difficile/drug effects/*genetics/*isolation & purification [MESH] |Enterocolitis, Pseudomembranous/drug therapy/microbiology [MESH] |Fluoroquinolones/therapeutic use [MESH] |Genetic Variation/genetics [MESH] |Genome, Bacterial/*genetics [MESH] |Germany [MESH] |Hospitalization [MESH] |Humans [MESH] |Microbial Sensitivity Tests/methods [MESH] |Phylogeography/methods [MESH]Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Ba(epmc).pdf DeepDyve Pubget Overpricing