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2015 ; 2
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Clinical Trial Laboratory Data Nested With in Subject: Components of Variance,
Sample Size and Cost
#MMPMID26457336
Jovanovic BD
; Subramanian H
; Helenowski IB
; Roy HK
; Backman V
Biom Biostat Int J
2015[]; 2
(3
): ä PMID26457336
show ga
Nesting of experimental factors is well established in statistical design
literature related to agricultural, environmental and engineering studies. It is
perhaps not sufficiently discussed in biological and laboratory experiments
stemming from the use of human bio-specimens, where sample size considerations
are often provided a priori on subject level, but there is little advice
regarding the needed number of units at lower levels. Motivated by an example
from spectroscopic microscopy and lung cancer, we revisit the experimental
nesting frame work and discuss how variability, cost of sampling and sample size
at lower levels may be coherently utilized. We show how the number of subjects
may have to be adjusted to account for inadequate sampling decisions made at
lower levels.