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2015 ; 29 Suppl 1
(0 1
): S91-8
Nephropedia Template TP
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English Wikipedia
Disclosure of their HIV status to perinatally infected youth using the adapted
Blasini disclosure model in Haiti and the Dominican Republic: preliminary
results
#MMPMID26049543
Beck-Sagué CM
; Dévieux J
; Pinzón-Iregui MC
; Lerebours-Nadal L
; Abreu-Pérez R
; Bertrand R
; Rouzier V
; Gaston S
; Ibanez G
; Halpern M
; Pape JW
; Dorceus P
; Preston SM
; Dean AG
; Nicholas SW
; Blasini I
AIDS
2015[Jun]; 29 Suppl 1
(0 1
): S91-8
PMID26049543
show ga
OBJECTIVES: To assess the safety, acceptability, and preliminary efficacy of a
culturally-adapted disclosure intervention for perinatally HIV-infected combined
antiretroviral therapy patients in Haiti and the Dominican Republic. DESIGN: A
quasi-experimental trial was conducted comparing caregiver-youth pairs who
completed the intervention [adapted Blasini disclosure model (aBDM)] to pairs who
discontinued aBDM participation before disclosure. aBDM consists of five
components: structured healthcare worker training; one-on one pre-disclosure
intervention/education sessions for youth (describing pediatric chronic diseases
including cancer, diabetes and HIV) and for caregivers (strengthening capacity
for disclosure); a scheduled supportive disclosure session; and one-on-one
postdisclosure support for caregivers and youth. METHODS: Caregivers of
nondisclosed combined antiretroviral therapy patients aged 10.0-17.8 years were
invited to participate. Data were collected by separate one-on-one face-to-face
interviews of caregivers and youth by study staff and medical record review by
pediatricians at enrollment and 3 months after disclosure or after intervention
discontinuation. RESULTS: To date, 65 Dominican Republic and 27 Haiti
caregiver-youth pairs have enrolled. At enrollment, only 46.4% of youth had viral
suppression and 43.4% of caregivers had clinically significant depressive
symptomatology. To date, two serious study-related adverse events have occurred.
Seven of the 92 (7.6%, 6 in the Dominican Republic) enrolled pairs discontinued
participation before disclosure and 39 had completed postdisclosure
participation. Median plasma HIV-RNA concentration was lower in youth who
completed aBDM than in youth who discontinued participation before aBDM
disclosure (<40 versus 8673 copies/ml; P?=?0.027). Completers expressed
considerable satisfaction with aBDM. CONCLUSION: Preliminary results suggest
safety, acceptability, and possible effectiveness of the aBDM.