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Immunobiology of Interleukin-37: Mechanism of Action and Clinical Perspectives #MMPMID25327443
Quirk S; Agrawal DK
Expert Rev Clin Immunol 2014[Dec]; 10 (12): 1703-9 PMID25327443show ga
This article provides an overview of the biological function of a recently discovered cytokine, interleukin-37 (IL-37), formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the last decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically reviewed the published reports. Future research is necessary in order to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states, and its potential role as a biomarker and pharmacological target in human disease.