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10.1164/rccm.201501-0148OC

http://scihub22266oqcxt.onion/10.1164/rccm.201501-0148OC
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C4595690!4595690!26030696
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suck abstract from ncbi


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pmid26030696      Am+J+Respir+Crit+Care+Med 2015 ; 192 (5): 559-69
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  • A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes #MMPMID26030696
  • Cho MH; Castaldi PJ; Hersh CP; Hobbs BD; Barr RG; Tal-Singer R; Bakke P; Gulsvik A; San José Estépar R; Van Beek EJR; Coxson HO; Lynch DA; Washko GR; Laird NM; Crapo JD; Beaty TH; Silverman EK
  • Am J Respir Crit Care Med 2015[Sep]; 192 (5): 559-69 PMID26030696show ga
  • Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These differences may be driven by genetic factors. We hypothesized that a genome-wide association study (GWAS) of quantitative imaging would identify loci not previously identified in analyses of COPD or spirometry. In addition, we sought to determine whether previously described genome-wide significant COPD and spirometric loci were associated with emphysema or airway phenotypes.Objectives: To identify genetic determinants of quantitative imaging phenotypes.Methods: We performed a GWAS on two quantitative emphysema and two quantitative airway imaging phenotypes in the COPDGene (non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints), NETT (National Emphysema Treatment Trial), and GenKOLS (Genetics of COPD, Norway) studies and on percentage gas trapping in COPDGene. We also examined specific loci reported as genome-wide significant for spirometric phenotypes related to airflow limitation or COPD.Measurements and Main Results: The total sample size across all cohorts was 12,031, of whom 9,338 were from COPDGene. We identified five loci associated with emphysema-related phenotypes, one with airway-related phenotypes, and two with gas trapping. These loci included previously reported associations, including the HHIP, 15q25, and AGER loci, as well as novel associations near SERPINA10 and DLC1. All previously reported COPD and a significant number of spirometric GWAS loci were at least nominally (P?
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