Design of optimal light delivery system for co-registered transvaginal ultrasound
and photoacoustic imaging of ovarian tissue
#MMPMID26640774
Salehi HS
; Kumavor PD
; Li H
; Alqasemi U
; Wang T
; Xu C
; Zhu Q
Photoacoustics
2015[Sep]; 3
(3
): 114-22
PMID26640774
show ga
A hand-held transvaginal probe suitable for co-registered photoacoustic and
ultrasound imaging of ovarian tissue was designed and evaluated. The imaging
probe consists of an ultrasound transducer and four 1-mm-core multi-mode optical
fibers both housed in a custom-made sheath. The probe was optimized for the
highest light delivery output and best beam uniformity on tissue surface, by
simulating the light fluence and power output for different design parameters.
The laser fluence profiles were experimentally measured through chicken breast
tissue and calibrated intralipid solution at various imaging depths. Polyethylene
tubing filled with rat blood mimicking a blood vessel was successfully imaged up
to ?30 mm depth through porcine vaginal tissue at 750 nm. This imaging depth was
achieved with a laser fluence on the tissue surface of 20 mJ/cm(2), which is
below the maximum permissible exposure (MPE) of 25 mJ/cm(2) recommended by the
American National Standards Institute (ANSI). Furthermore, the probe imaging
capability was verified with ex vivo imaging of benign and malignant human
ovaries. The co-registered images clearly showed different vasculature
distributions on the surface of the benign cyst and the malignant ovary. These
results suggest that our imaging system has the clinical potential for in vivo
imaging and characterization of ovarian tissues.
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