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2015 ; 20
(6
): 885-92
Nephropedia Template TP
gab.com Text
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English Wikipedia
The detection and role of heat shock protein 70 in various nondisease conditions
and disease conditions: a literature review
#MMPMID26139132
Qu B
; Jia Y
; Liu Y
; Wang H
; Ren G
; Wang H
Cell Stress Chaperones
2015[Nov]; 20
(6
): 885-92
PMID26139132
show ga
As an intracellular polypeptide, heat shock protein 70 (HSP70) can be exposed on
the plasma membrane and/or released into the circulation. However, the role of
HSP70 in various nondisease and disease conditions remains unknown. Quantitative
methods for the detection of HSP70 have been used in clinical studies, revealing
that an increase in circulating HSP70 is associated with various types of
exercise, elderly patients presenting with inflammation, mobile phones,
inflammation, sepsis, chronic obstructive pulmonary disease, asthma, carotid
intima-media thickness, glutamine-treated ill patients, mortality, diabetes
mellitus, active chronic glomerulonephritis, and cancers. Circulating HSP70
decreases with age in humans and in obstructive sleep apnea, arteriosclerosis,
atrial fibrillation (AF) following coronary artery bypass surgery, nonalcoholic
fatty liver disease, moderate-to-severe alcoholic fatty liver disease, hepatic
steatosis, and Helicobacter pylori infection. In conclusion, quantitative methods
can be used to detect HSP70, particularly in determining circulating HSP70
levels, using more convenient and rapid screening methods. Studies have shown
that changes in HSP70 are associated with various nondisease and disease
conditions; thus, HSP70 might be a novel potential biomarker reflecting various
nondisease conditions and also the severity of disease conditions. However, the
reliability and accuracy, as well as the underlying mechanism, of this
relationship remain poorly understood, and large-sample clinical research must be
performed to verify the role.