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10.1371/journal.pone.0138952

http://scihub22266oqcxt.onion/10.1371/journal.pone.0138952
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C4595419!4595419!26439935
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suck abstract from ncbi


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pmid26439935      PLoS+One 2015 ; 10 (10): ä
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  • Accuracy of QuantiFERON-TB Gold Test for Tuberculosis Diagnosis in Children #MMPMID26439935
  • Sali M; Buonsenso D; Goletti D; D?Alfonso P; Zumbo A; Fadda G; Sanguinetti M; Delogu G; Valentini P
  • PLoS One 2015[]; 10 (10): ä PMID26439935show ga
  • Objectives: To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI). Methods: A retrospective study was conducted on 621 children (0?14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay. Results: Among the 140 active TB suspects, we identified 19 cases of active disease. The overall sensitivity for active TB was 87.5%, ranging from 62.5% in children 25?36 months old to 100% in children older than 49 months. The overall specificity for active TB was 93.6%. Among the 481 children tested for LTBI screening, 38 scored positive and all but 2 had at least one risk factor for TB infection. Among the 26 children with indeterminate results, bacterial, viral or fungal pneumonia were later diagnosed in 11 (42.3%) cases and non-TB related extra-pulmonary infections in 12 (46.1%). Conclusions: Our results indicate that the children's response to QFT-IT associates to active TB and risk factors for LTBI. Moreover, we show that mitogen response is also found in children of 1 year of age, providing support for QFT-IT use also in young children.
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