Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26284468
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Immunol+Rev
2015 ; 267
(1
): 6-15
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons
from cold-blooded vertebrates
#MMPMID26284468
Ohta Y
; Flajnik MF
Immunol Rev
2015[Sep]; 267
(1
): 6-15
PMID26284468
show ga
Comparative immunology provides the long view of what is conserved across all
vertebrate taxa versus what is specific to particular organisms or group of
organisms. Regarding the major histocompatibility complex (MHC) and coevolution,
three striking cases have been revealed in cold-blooded vertebrates: lineages of
class Ia antigen-processing and -presenting genes, evolutionary conservation of
NKT-class Ib recognition, and the ancient emergence of the natural cytotoxicity
receptor NKp30 and its ligand B7H6. While coevolution of transporter associated
with antigen processing (TAP) and class Ia has been documented in endothermic
birds and two mammals, lineages of LMP7 are restricted to ectotherms. The
unambiguous discovery of natural killer T (NKT) cells in Xenopus demonstrated
that NKT cells are not restricted to mammals and are likely to have emerged at
the same time in evolution as classical ?/? and ?/? T cells. NK cell receptors
evolve at a rapid rate, and orthologues are nearly impossible to identify in
different vertebrate classes. By contrast, we have detected NKp30 in all
gnathostomes, except in species where it was lost. The recently discovered ligand
of NKp30, B7H6, shows strong signs of coevolution with NKp30 throughout
evolution, i.e. coincident loss or expansion of both genes in some species. NKp30
also offers an attractive IgSF candidate for the invasion of the RAG transposon,
which is believed to have initiated T-cell receptor/immunoglobulin adaptive
immunity. Besides reviewing these intriguing features of MHC evolution and
coevolution, we offer suggestions for future studies and propose a model for the
primordial or proto MHC.
|Animals
[MESH]
|B7 Antigens/genetics/immunology
[MESH]
|Evolution, Molecular
[MESH]
|Histocompatibility Antigens Class I/genetics/immunology
[MESH]
|Histocompatibility Antigens Class II/genetics/immunology
[MESH]
free
free
free
