Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26119132
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26119132
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2015 ; 19
(10
): 2307-23
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The circulating transcriptome as a source of non-invasive cancer biomarkers:
concepts and controversies of non-coding and coding RNA in body fluids
#MMPMID26119132
Fernandez-Mercado M
; Manterola L
; Larrea E
; Goicoechea I
; Arestin M
; Armesto M
; Otaegui D
; Lawrie CH
J Cell Mol Med
2015[Oct]; 19
(10
): 2307-23
PMID26119132
show ga
The gold standard for cancer diagnosis remains the histological examination of
affected tissue, obtained either by surgical excision, or radiologically guided
biopsy. Such procedures however are expensive, not without risk to the patient,
and require consistent evaluation by expert pathologists. Consequently, the
search for non-invasive tools for the diagnosis and management of cancer has led
to great interest in the field of circulating nucleic acids in plasma and serum.
An additional benefit of blood-based testing is the ability to carry out
screening and repeat sampling on patients undergoing therapy, or monitoring
disease progression allowing for the development of a personalized approach to
cancer patient management. Despite having been discovered over 60 years ago, the
clear clinical potential of circulating nucleic acids, with the notable exception
of prenatal diagnostic testing, has yet to translate into the clinic. The recent
discovery of non-coding (nc) RNA (in particular micro(mi)RNAs) in the blood has
provided fresh impetuous for the field. In this review, we discuss the potential
of the circulating transcriptome (coding and ncRNA), as novel cancer biomarkers,
the controversy surrounding their origin and biology, and most importantly the
hurdles that remain to be overcome if they are really to become part of future
clinical practice.