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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Organogenesis 2015 ; 11 (1): 1-15 Nephropedia Template TP
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Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression #MMPMID25915734
Handorf AM; Zhou Y; Halanski MA; Li WJ
Organogenesis 2015[Jan]; 11 (1): 1-15 PMID25915734show ga
Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression.