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10.4161/19336918.2014.972761 http://scihub22266oqcxt.onion/10.4161/19336918.2014.972761 C4594578!4594578 !25482627     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25482627 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Adh+Migr 2015 ; 9 (4 ): 265-76 Nephropedia Template TP {{tp|p=25482627 |t=2015. Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis |pdf=|usr=}}{{25482627 }} gab.com Text Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis JO: Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=25482627 #FOAvip Although phenotypic intratumoral heterogeneity was first described many decades ago, the advent of next-generation sequencing has provided conclusive evidence that in addition to phenotypic diversity, significant genotypic diversity exists within tumors. Tumor heterogeneity likely arises both from clonal expansions, as well as from differentiation hierarchies existent in the tumor, such as that established by cancer stem cells (CSCs) and non-CSCs. These differentiation hierarchies may arise due to genetic mutations, epigenetic alterations, or microenvironmental influences. An additional differentiation hierarchy within epithelial tumors may arise when only a few tumor cells trans-differentiate into mesenchymal-like cells, a process known as epithelial-to-mesenchymal transition (EMT). Again, this process can be influenced by both genetic and non-genetic factors. In this review we discuss the evidence for clonal interaction and cooperation for tumor maintenance and progression, particularly with respect to EMT, and further address the far-reaching effects that tumor heterogeneity may have on cancer therapy. Twit Text FOAVip Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis ????Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=25482627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25482627 #FOAvip English Wikipedia <ref>{{Cite pmid|25482627 }}</ref> Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis #MMPMID25482627 Neelakantan D ; Drasin DJ ; Ford HL Cell Adh Migr 2015[]; 9 (4 ): 265-76 PMID25482627 show ga Although phenotypic intratumoral heterogeneity was first described many decades ago, the advent of next-generation sequencing has provided conclusive evidence that in addition to phenotypic diversity, significant genotypic diversity exists within tumors. Tumor heterogeneity likely arises both from clonal expansions, as well as from differentiation hierarchies existent in the tumor, such as that established by cancer stem cells (CSCs) and non-CSCs. These differentiation hierarchies may arise due to genetic mutations, epigenetic alterations, or microenvironmental influences. An additional differentiation hierarchy within epithelial tumors may arise when only a few tumor cells trans-differentiate into mesenchymal-like cells, a process known as epithelial-to-mesenchymal transition (EMT). Again, this process can be influenced by both genetic and non-genetic factors. In this review we discuss the evidence for clonal interaction and cooperation for tumor maintenance and progression, particularly with respect to EMT, and further address the far-reaching effects that tumor heterogeneity may have on cancer therapy. |Cell Differentiation/genetics/physiology [MESH] |Epithelial-Mesenchymal Transition/genetics/*physiology [MESH] |Humans [MESH]Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenc(epmc).pdf DeepDyve Pubget Overpricing