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10.1080/19420889.2015.1034400 http://scihub22266oqcxt.onion/10.1080/19420889.2015.1034400 C4594419!4594419!26479042     free     free     free       Commun+Integr+Biol 2015 ; 8 (3): ä Nephropedia Template TP {{tp|p=26479042|t=2015. New insights into the functions of intersectin-1s |pdf=|usr=}}{{26479042}} gab.com Text New insights into the functions of intersectin-1s JO: Commun Integr Biol http://www.kidney.de/pget.php?&tw=1&pmid=26479042 #FOAvip Intersectin-1s (ITSN) is a ubiquitously expressed multifunctional protein known as a scaffold and regulator of the general endocytic machinery as well as a critical integrator of cellular signaling pathways. We showed recently that ITSN deficiency triggers a transforming growth factor ? (TGF?)/Alk5 signaling switch, from the canonical Smad 2/3 to the Erk1/2 MAPK pathway; moreover, endocytic impairment induced by ITSN deficiency enhances Alk5 ubiquitination and degradation and elicits TGF?-paracrine effects mediated by circulating microparticles, leading to endothelial cell survival and increased proliferation. The studies expand our understanding of how ITSN facilitates cross-regulation of signaling pathways and provide insights into the involvement of ITSN deficiency in human disease. Twit Text FOAVip New insights into the functions of intersectin-1s ????Commun Integr Biol http://www.kidney.de/pget.php?&tw=1&pmid=26479042 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26479042 #FOAvip English Wikipedia <ref>{{Cite pmid|26479042}}</ref> New insights into the functions of intersectin-1s #MMPMID26479042 Predescu S; Bardita C; Predescu D Commun Integr Biol 2015[May]; 8 (3): ä PMID26479042show ga Intersectin-1s (ITSN) is a ubiquitously expressed multifunctional protein known as a scaffold and regulator of the general endocytic machinery as well as a critical integrator of cellular signaling pathways. We showed recently that ITSN deficiency triggers a transforming growth factor ? (TGF?)/Alk5 signaling switch, from the canonical Smad 2/3 to the Erk1/2 MAPK pathway; moreover, endocytic impairment induced by ITSN deficiency enhances Alk5 ubiquitination and degradation and elicits TGF?-paracrine effects mediated by circulating microparticles, leading to endothelial cell survival and increased proliferation. The studies expand our understanding of how ITSN facilitates cross-regulation of signaling pathways and provide insights into the involvement of ITSN deficiency in human disease. äNew insights into the functions of intersectin-1s (epmc).pdf DeepDyve Pubget Overpricing