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10.1038/aps.2014.169 http://scihub22266oqcxt.onion/10.1038/aps.2014.169 C4594178!4594178 !25937635     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25937635 &cmd=llinks): Failed to open stream: HTTP request failed! 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An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China |pdf=|usr=}}{{25937635 }} gab.com Text An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25937635 #FOAvip AIM: To investigate specific changes in metabolites and proteins of Kidney-Yin Deficiency Syndrome (KYDS) patients with diabetes mellitus (DM) in China. METHODS: KYDS (n=29) and non-KYDS (n=23) patients with DM were recruited for this study. The KYDS was diagnosed by two senior TCM clinicians separately. The metabonomic and proteomic profiles of the patients were assessed using a metabonomic strategy based on NMR with multivariate analysis and a proteomic strategy based on MALDI-TOF-MS, respectively. RESULTS: Eighteen upregulated peptides and thirty downregulated peptides were observed in the plasma of the KYDS patients. Comparing the proteomic profiles of the KYDS and non-KYDS groups, however, no significantly differentially expressed peptides were found. At the same time, major metabolic alterations were found to distinguish the two groups, including eight significantly changed metabolites (creatinine, citrate, TMAO, phenylalanine, tyrosine, alanine, glycine and taurine). The levels of creatinine, citrate, TMAO, phenylalanine and tyrosine were decreased, whereas the levels of alanine, glycine and taurine were increased in the KYDS patients. These biochemical changes were found to be associated with alterations in amino acid metabolism, energy metabolism and gut microflora. CONCLUSION: The identification of distinct expression profiles of metabolites and signaling pathways in KYDS patients with DM suggests that there are indeed molecular signatures underlying the principles of 'Syndrome Differentiation' in traditional Chinese medicine. Twit Text FOAVip An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25937635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25937635 #FOAvip English Wikipedia <ref>{{Cite pmid|25937635 }}</ref> An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China #MMPMID25937635 Jiang N ; Liu HF ; Li SD ; Zhou WX ; Zhang YX ; Zhang Q ; Yan XZ Acta Pharmacol Sin 2015[Jun]; 36 (6 ): 689-98 PMID25937635 show ga AIM: To investigate specific changes in metabolites and proteins of Kidney-Yin Deficiency Syndrome (KYDS) patients with diabetes mellitus (DM) in China. METHODS: KYDS (n=29) and non-KYDS (n=23) patients with DM were recruited for this study. The KYDS was diagnosed by two senior TCM clinicians separately. The metabonomic and proteomic profiles of the patients were assessed using a metabonomic strategy based on NMR with multivariate analysis and a proteomic strategy based on MALDI-TOF-MS, respectively. RESULTS: Eighteen upregulated peptides and thirty downregulated peptides were observed in the plasma of the KYDS patients. Comparing the proteomic profiles of the KYDS and non-KYDS groups, however, no significantly differentially expressed peptides were found. At the same time, major metabolic alterations were found to distinguish the two groups, including eight significantly changed metabolites (creatinine, citrate, TMAO, phenylalanine, tyrosine, alanine, glycine and taurine). The levels of creatinine, citrate, TMAO, phenylalanine and tyrosine were decreased, whereas the levels of alanine, glycine and taurine were increased in the KYDS patients. These biochemical changes were found to be associated with alterations in amino acid metabolism, energy metabolism and gut microflora. CONCLUSION: The identification of distinct expression profiles of metabolites and signaling pathways in KYDS patients with DM suggests that there are indeed molecular signatures underlying the principles of 'Syndrome Differentiation' in traditional Chinese medicine. |Aged [MESH] |Biomarkers/blood/urine [MESH] |Blood Proteins/*analysis [MESH] |Case-Control Studies [MESH] |China [MESH] |Diabetes Mellitus/*blood/diagnosis/*urine [MESH] |Female [MESH] |Humans [MESH] |Kidney/*metabolism [MESH] |Male [MESH] |Metabolomics/*methods [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Predictive Value of Tests [MESH] |Proteomics/*methods [MESH] |Proton Magnetic Resonance Spectroscopy [MESH] |Signal Transduction [MESH] |Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization [MESH] |Systems Biology [MESH] |Systems Integration [MESH] |Urinalysis [MESH]An integrated metabonomic and proteomic study on Kidney-Yin Deficiency(epmc).pdf DeepDyve Pubget Overpricing