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10.1186/s40880-015-0051-5 http://scihub22266oqcxt.onion/10.1186/s40880-015-0051-5 C4593342!4593342 !26369565     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26369565 &cmd=llinks): Failed to open stream: HTTP request failed! 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Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy |pdf=|usr=}}{{26369565 }} gab.com Text Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy JO: Chin J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26369565 #FOAvip Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipient cells, and induce malignant transformation. This review will therefore discuss the potential of stem cell-derived exosomes in the context of stromal remodeling and their ability to generate cancer-initiating cells in a tumor niche by inducing morphologic and functional differentiation of fibroblasts into tumor-initiating fibroblasts. In addition, the immunosuppressive potential of stem cell-derived exosomes in cancer immunotherapy and their prospective applications in cell-free therapies in future translational medicine is discussed. Twit Text FOAVip Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy ????Chin J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26369565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26369565 #FOAvip English Wikipedia <ref>{{Cite pmid|26369565 }}</ref> Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy #MMPMID26369565 Fatima F ; Nawaz M Chin J Cancer 2015[Sep]; 34 (12 ): 541-53 PMID26369565 show ga Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipient cells, and induce malignant transformation. This review will therefore discuss the potential of stem cell-derived exosomes in the context of stromal remodeling and their ability to generate cancer-initiating cells in a tumor niche by inducing morphologic and functional differentiation of fibroblasts into tumor-initiating fibroblasts. In addition, the immunosuppressive potential of stem cell-derived exosomes in cancer immunotherapy and their prospective applications in cell-free therapies in future translational medicine is discussed. |Apoptosis [MESH] |Cell Communication [MESH] |Cell Transformation, Neoplastic [MESH] |Disease Progression [MESH] |Exosomes/*physiology [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Mesenchymal Stem Cells/*physiology [MESH] |Neoplasms/blood supply/*pathology/therapy [MESH] |Neoplastic Stem Cells/*ultrastructure [MESH] |Neovascularization, Pathologic/pathology [MESH] |Organelle Biogenesis [MESH]Stem cell-derived exosomes: roles in stromal remodeling, tumor progres(epmc).pdf DeepDyve Pubget Overpricing