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2015 ; 109
(5
): 511-21
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS:
Multiple-Organ Injury Consequent to 10 Gy Total Body Irradiation
#MMPMID26425910
Unthank JL
; Miller SJ
; Quickery AK
; Ferguson EL
; Wang M
; Sampson CH
; Chua HL
; DiStasi MR
; Feng H
; Fisher A
; Katz BP
; Plett PA
; Sandusky GE
; Sellamuthu R
; Vemula S
; Cohen EP
; MacVittie TJ
; Orschell CM
Health Phys
2015[Nov]; 109
(5
): 511-21
PMID26425910
show ga
The threat of radiation exposure from warfare or radiation accidents raises the
need for appropriate animal models to study the acute and chronic effects of high
dose rate radiation exposure. The goal of this study was to assess the late
development of fibrosis in multiple organs (kidney, heart, and lung) in survivors
of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS).
Separate groups of mice for histological and functional studies were exposed to a
single uniform total body dose between 8.53 and 8.72 Gy of gamma radiation from a
Cs radiation source and studied 1-21 mo later. Blood urea nitrogen levels were
elevated significantly in the irradiated mice at 9 and 21 mo (from ?22 to 34 ±
3.8 and 69 ± 6.0 mg dL, p < 0.01 vs. non-irradiated controls) and correlated with
glomerosclerosis (29 ± 1.8% vs. 64 ± 9.7% of total glomeruli, p < 0.01 vs.
non-irradiated controls). Glomerular tubularization and hypertrophy and tubular
atrophy were also observed at 21 mo post-total body irradiation (TBI). An
increase in interstitial, perivascular, pericardial and peribronchial
fibrosis/collagen deposition was observed from ?9-21 mo post-TBI in kidney,
heart, and lung of irradiated mice relative to age-matched controls.
Echocardiography suggested decreased ventricular volumes with a compensatory
increase in the left ventricular ejection fraction. The results indicate that
significant delayed effects of acute radiation exposure occur in kidney, heart,
and lung in survivors of the murine H-ARS TBI model, which mirrors pathology
detected in larger species and humans at higher radiation doses focused on
specific organs.