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10.1097/HP.0000000000000354 http://scihub22266oqcxt.onion/10.1097/HP.0000000000000354 C4593318!4593318!26425900     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Health+Phys 2015 ; 109 (5): 391-8 Nephropedia Template TP {{tp|p=26425900|t=2015. The H-ARS Dose Response Relationship (DRR): Validation and Variables |pdf=|usr=}}{{26425900}} gab.com Text The H-ARS Dose Response Relationship (DRR): Validation and Variables JO: Health Phys http://www.kidney.de/pget.php?&tw=1&pmid=26425900 #FOAvip Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrome, 20 individual survival efficacy studies were grouped based on the severity of the administration (Admn) schedules of their medical countermeasure (MCM) into Admn 1 (no injections), Admn 2 (one to three injections), or Admn 3 (29 injections or six to nine oral gavages). Radiation doses ranged from LD30/30 to LD95/30. Thirty-day survival of vehicle controls in each group was used to construct radiation dose lethality response relationship (DRR) probit plots, which were compared statistically to the original DRR from which all LDXX/30 for the studies were obtained. The slope of the Admn 3 probit was found to be significantly steeper (5.190) than that of the original DRR (2.842) or Admn 2 (2.009), which were not significantly different. The LD50/30 for Admn 3 (8.43 Gy) was less than that of the original DRR (8.53 Gy, p<0.050), whereas the LD50/30 of other groups were similar. Kaplan-Meier survival curves showed significantly worse survival of Admn 3 mice compared to the three other groups (p=0.007). Taken together, these results show that stressful administration schedules of MCM can negatively impact survival, and that dosing regimens should be considered when constructing DRR to use in survival studies. Twit Text FOAVip The H-ARS Dose Response Relationship (DRR): Validation and Variables ????Health Phys http://www.kidney.de/pget.php?&tw=1&pmid=26425900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26425900 #FOAvip English Wikipedia <ref>{{Cite pmid|26425900}}</ref> The H-ARS Dose Response Relationship (DRR): Validation and Variables #MMPMID26425900 Plett PA; Sampson CH; Chua HL; Jackson W; Vemula S; Sellamuthu R; Fisher A; Feng H; Wu T; MacVittie TJ; Orschell CM Health Phys 2015[Nov]; 109 (5): 391-8 PMID26425900show ga Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrome, 20 individual survival efficacy studies were grouped based on the severity of the administration (Admn) schedules of their medical countermeasure (MCM) into Admn 1 (no injections), Admn 2 (one to three injections), or Admn 3 (29 injections or six to nine oral gavages). Radiation doses ranged from LD30/30 to LD95/30. Thirty-day survival of vehicle controls in each group was used to construct radiation dose lethality response relationship (DRR) probit plots, which were compared statistically to the original DRR from which all LDXX/30 for the studies were obtained. The slope of the Admn 3 probit was found to be significantly steeper (5.190) than that of the original DRR (2.842) or Admn 2 (2.009), which were not significantly different. The LD50/30 for Admn 3 (8.43 Gy) was less than that of the original DRR (8.53 Gy, p<0.050), whereas the LD50/30 of other groups were similar. Kaplan-Meier survival curves showed significantly worse survival of Admn 3 mice compared to the three other groups (p=0.007). Taken together, these results show that stressful administration schedules of MCM can negatively impact survival, and that dosing regimens should be considered when constructing DRR to use in survival studies. äThe H-ARS Dose Response Relationship (DRR): Validation and Variables (epmc).pdf DeepDyve Pubget Overpricing