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10.1136/bmjopen-2015-009368 http://scihub22266oqcxt.onion/10.1136/bmjopen-2015-009368 C4593136!4593136 !26423858     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26423858 &cmd=llinks): Failed to open stream: HTTP request failed! 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Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey |pdf=|usr=}}{{26423858 }} gab.com Text Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey JO: BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=26423858 #FOAvip OBJECTIVES: To describe how systematic reviewers are reporting missing data for dichotomous outcomes, handling them in the analysis and assessing the risk of associated bias. METHODS: We searched MEDLINE and the Cochrane Database of Systematic Reviews for systematic reviews of randomised trials published in 2010, and reporting a meta-analysis of a dichotomous outcome. We randomly selected 98 Cochrane and 104 non-Cochrane systematic reviews. Teams of 2 reviewers selected eligible studies and abstracted data independently and in duplicate using standardised, piloted forms with accompanying instructions. We conducted regression analyses to explore factors associated with using complete case analysis and with judging the risk of bias associated with missing participant data. RESULTS: Of Cochrane and non-Cochrane reviews, 47% and 7% (p<0.0001), respectively, reported on the number of participants with missing data, and 41% and 9% reported a plan for handling missing categorical data. The 2 most reported approaches for handling missing data were complete case analysis (8.5%, out of the 202 reviews) and assuming no participants with missing data had the event (4%). The use of complete case analysis was associated only with Cochrane reviews (relative to non-Cochrane: OR=7.25; 95% CI 1.58 to 33.3, p=0.01). 65% of reviews assessed risk of bias associated with missing data; this was associated with Cochrane reviews (relative to non-Cochrane: OR=6.63; 95% CI 2.50 to 17.57, p=0.0001), and the use of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology (OR=5.02; 95% CI 1.02 to 24.75, p=0.047). CONCLUSIONS: Though Cochrane reviews are somewhat less problematic, most Cochrane and non-Cochrane systematic reviews fail to adequately report and handle missing data, potentially resulting in misleading judgements regarding risk of bias. Twit Text FOAVip Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey ????BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=26423858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26423858 #FOAvip English Wikipedia <ref>{{Cite pmid|26423858 }}</ref> Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey #MMPMID26423858 Akl EA ; Carrasco-Labra A ; Brignardello-Petersen R ; Neumann I ; Johnston BC ; Sun X ; Briel M ; Busse JW ; Ebrahim S ; Granados CE ; Iorio A ; Irfan A ; Martínez García L ; Mustafa RA ; Ramírez-Morera A ; Selva A ; Solà I ; Sanabria AJ ; Tikkinen KA ; Vandvik PO ; Vernooij RW ; Zazueta OE ; Zhou Q ; Guyatt GH ; Alonso-Coello P BMJ Open 2015[Sep]; 5 (9 ): e009368 PMID26423858 show ga OBJECTIVES: To describe how systematic reviewers are reporting missing data for dichotomous outcomes, handling them in the analysis and assessing the risk of associated bias. METHODS: We searched MEDLINE and the Cochrane Database of Systematic Reviews for systematic reviews of randomised trials published in 2010, and reporting a meta-analysis of a dichotomous outcome. We randomly selected 98 Cochrane and 104 non-Cochrane systematic reviews. Teams of 2 reviewers selected eligible studies and abstracted data independently and in duplicate using standardised, piloted forms with accompanying instructions. We conducted regression analyses to explore factors associated with using complete case analysis and with judging the risk of bias associated with missing participant data. RESULTS: Of Cochrane and non-Cochrane reviews, 47% and 7% (p<0.0001), respectively, reported on the number of participants with missing data, and 41% and 9% reported a plan for handling missing categorical data. The 2 most reported approaches for handling missing data were complete case analysis (8.5%, out of the 202 reviews) and assuming no participants with missing data had the event (4%). The use of complete case analysis was associated only with Cochrane reviews (relative to non-Cochrane: OR=7.25; 95% CI 1.58 to 33.3, p=0.01). 65% of reviews assessed risk of bias associated with missing data; this was associated with Cochrane reviews (relative to non-Cochrane: OR=6.63; 95% CI 2.50 to 17.57, p=0.0001), and the use of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology (OR=5.02; 95% CI 1.02 to 24.75, p=0.047). CONCLUSIONS: Though Cochrane reviews are somewhat less problematic, most Cochrane and non-Cochrane systematic reviews fail to adequately report and handle missing data, potentially resulting in misleading judgements regarding risk of bias. |*Bias [MESH] |*Data Accuracy [MESH] |*Meta-Analysis as Topic [MESH] |*Review Literature as Topic [MESH] |Humans [MESH] |Research Design/standards [MESH]Reporting, handling and assessing the risk of bias associated with mis(epmc).pdf DeepDyve Pubget Overpricing