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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol+Res
2015 ; 2015
(ä): 902863
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High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food
Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?
#MMPMID26484355
Sekerkova A
; Fuchs M
; Cecrdlova E
; Svachova V
; Kralova Lesna I
; Striz I
; Tlaskalova-Hogenova H
J Immunol Res
2015[]; 2015
(ä): 902863
PMID26484355
show ga
Background. Food protein-induced proctitis/proctocolitis (FPIP) is the most
common noninfectious colitis in children in the first year of life. Along with
the overall clinical symptoms, diarrhoea and rectal bleeding are the main
manifestations of the disease. There is no routine noninvasive test that would be
specific for this type of colitis. The aim of our study was to find a noninvasive
laboratory test or tests that may be helpful in differential diagnosis of food
protein-induced proctitis/proctocolitis. Methods. ANA, ANCA, ASCA, a-EMA, a-tTg,
specific IgE, total IgE, IgG, IgA, IgM, and concentration of serum calprotectin
were measured in a group of 25 patients with colitis and 18 children with other
diagnoses. Results. Atypical-pANCA antibodies of IgG isotype were detected in the
sera of 24 patients by the method of indirect immunofluorescence, and 5 patients
showed also the positivity of IgA isotype. In control samples these
autoantibodies were not detected. Other autoantibodies were not demonstrated in
either patient or control group. Conclusions. Of the parameters tested in
noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be
a suitable serological marker of food protein-induced proctitis/proctocolitis and
suggests a possible involvement of an autoimmune mechanisms in the pathogenesis
of this disease.