Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26431320
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26431320
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(10
): e0139824
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Intraovarian Transplantation of Female Germline Stem Cells Rescue Ovarian
Function in Chemotherapy-Injured Ovaries
#MMPMID26431320
Xiong J
; Lu Z
; Wu M
; Zhang J
; Cheng J
; Luo A
; Shen W
; Fang L
; Zhou S
; Wang S
PLoS One
2015[]; 10
(10
): e0139824
PMID26431320
show ga
Early menopause and infertility often occur in female cancer patients after
chemotherapy (CTx). For these patients, oocyte/embryo cryopreservation or ovarian
tissue cryopreservation is the current modality for fertility preservation.
However, the above methods are limited in the long-term protection of ovarian
function, especially for fertility preservation (very few females with cancer
have achieved pregnancy with cryopreserved ovarian tissue or eggs until now). In
addition, the above methods are subject to their scope (females with no husband
or prepubertal females with no mature oocytes). Thus, many females who suffer
from cancers would not adopt the above methods pre- and post-CTx due to their
uncertainty, safety and cost-effectiveness. Therefore, millions of women have
achieved long-term survival after thorough CTx treatment and have desired to
rescue their ovarian function and fertility with economic, durable and reliable
methods. Recently, some studies showed that mice with infertility caused by CTx
can produce normal offspring through intraovarian injection of exogenous female
germline stem cells (FGSCs). Though exogenous FGSC can be derived from mice
without immune rejection in the same strain, it is difficult to obtain human
female germline stem cells (hFGSCs), and immune rejection could occur between
different individuals. In this study, infertility in mice was caused by CTx, and
the ability of FGSCs to restore ovarian function or even produce offspring was
assessed. We had successfully isolated and purified the FGSCs from adult female
mice two weeks after CTx. After infection with GFP-carrying virus, the FGSCs were
transplanted into ovaries of mice with infertility caused by CTx. Finally,
ovarian function was restored and the recipients produced offspring long-term.
These findings showed that mice with CTx possessed FGSCs, restoring ovarian
function and avoiding immune rejection from exogenous germline stem cells.
free
free
free
