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10.2147/DDDT.S86269

http://scihub22266oqcxt.onion/10.2147/DDDT.S86269
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suck abstract from ncbi


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pmid26451092
      Drug+Des+Devel+Ther 2015 ; 9 (ä): 5397-405
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  • Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis #MMPMID26451092
  • Ba J ; Peng RS ; Xu D ; Li YH ; Shi H ; Wang Q ; Yu J
  • Drug Des Devel Ther 2015[]; 9 (ä): 5397-405 PMID26451092 show ga
  • AIMS: Age-related macular degeneration (AMD) is the main cause of blindness. Anti-vascular endothelial growth factor is used to prevent further neovascularization due to wet AMD. The purpose of this systematic review was to investigate the effect and protocol of anti-vascular endothelial growth factor treatment on wet AMD. METHODS: A comprehensive literature search was performed in PubMed, Embase, the Cochrane Library, CNKI, and reference lists. Meta-analysis was performed using Stata12.0 software, best corrected visual acuity (BCVA), retinal thickness, and lesion size were evaluated. RESULTS: Twelve randomized controlled trials spanning from 2010 to 2014 and involving 5,225 patients were included. A significant difference was observed between the intravitreal ranibizumab (IVR) group and the intravitreal bevacizumab group (standard mean difference = -0.14, 95% confidence interval [CI] = -0.23 to -0.05). No significant differences were observed in best corrected VA, retinal thickness, or lesion size between IVR and the intravitreal aflibercept group. Compared to monthly injection, IVR as-needed injections (PRN) can raise VA by 1.97 letters (weighted mean difference = 1.97, 95% CI = 0.14-3.794). Combination therapy of IVR and photodynamic therapy can significantly raise VA by 2.74 letters when combined with IVR monotherapy (weighted mean difference = 2.74, 95% CI = 0.26-5.21). CONCLUSION: The superiority remains unclear between IVR and intravitreal bevacizumab in the treatment of neovascular AMD. Intravitreal aflibercept dosed every 2 months required fewer injection times, but produced similar efficacy as monthly IVR. IVR PRN could significantly increase VA. Combined with photodynamic therapy, IVR therapy could also increase VA effectively.
  • |*Choroidal Neovascularization [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Angiogenesis Inhibitors/*administration & dosage/adverse effects [MESH]
  • |Animals [MESH]
  • |Bevacizumab/administration & dosage [MESH]
  • |Combined Modality Therapy [MESH]
  • |Humans [MESH]
  • |Intravitreal Injections [MESH]
  • |Odds Ratio [MESH]
  • |Photochemotherapy [MESH]
  • |Ranibizumab/administration & dosage [MESH]
  • |Receptors, Vascular Endothelial Growth Factor/administration & dosage [MESH]
  • |Recombinant Fusion Proteins/administration & dosage [MESH]
  • |Retina/*drug effects/metabolism/pathology [MESH]
  • |Signal Transduction/drug effects [MESH]
  • |Treatment Outcome [MESH]
  • |Vascular Endothelial Growth Factor A/*antagonists & inhibitors/metabolism [MESH]
  • |Visual Acuity/drug effects [MESH]


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