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10.1097/BOR.0000000000000111

http://scihub22266oqcxt.onion/10.1097/BOR.0000000000000111
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C4591932!4591932!25191993
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suck abstract from ncbi


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pmid25191993      Curr+Opin+Rheumatol 2014 ; 26 (6): 630-6
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  • Update on scleroderma-associated interstitial lung disease #MMPMID25191993
  • Fan MH; Feghali-Bostwick CA; Silver RM
  • Curr Opin Rheumatol 2014[Nov]; 26 (6): 630-6 PMID25191993show ga
  • Systemic sclerosis (SSc), or scleroderma, is a heterogeneous and complex autoimmune disease characterized by varying degrees of skin and organ fibrosis and obliterative vasculopathy. The disease results in significant morbidity and mortality and to date available treatments are limited. Lung involvement is currently the leading cause of death of patients with SSc. Over the past year, significant advances have been made in our understanding of SSc-associated lung disease and this review attempts to encapsulate these most recent findings and place them in context. We divide our discussion of the most recent literature into 1) clinical aspects of SSc lung management, including classification, imaging, biomarkers, and treatment; 2) promising new animal models that may improve our ability to accurately study this disease; and 3) studies that advance or change our understanding of lung disease pathogenesis, thereby raising the potential for new targets for therapeutic intervention. The goal of this review is to highlight and summarize the most significant studies of the past year and to bring clinicians and researchers alike in the field up to date.
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