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10.1074/jbc.M115.648345

http://scihub22266oqcxt.onion/10.1074/jbc.M115.648345
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suck abstract from ncbi


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pmid26269600      J+Biol+Chem 2015 ; 290 (40): 24100-18
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  • Modulator of Apoptosis 1 (MOAP-1) Is a Tumor Suppressor Protein Linked to the RASSF1A Protein* #MMPMID26269600
  • Law J; Salla M; Zare A; Wong Y; Luong L; Volodko N; Svystun O; Flood K; Lim J; Sung M; Dyck JRB; Tan CT; Su YC; Yu VC; Mackey J; Baksh S
  • J Biol Chem 2015[Oct]; 290 (40): 24100-18 PMID26269600show ga
  • Background: MOAP-1 is a pro-apoptotic protein.Results: MOAP-1 expression is reduced in cancers and high expression correlated with increased patient survival. MOAP-1 can associate with tubulin and modulate tubulin stability. Furthermore, loss of the BH3 domain of MOAP-1 resulted in lack of tumor suppressor function.Conclusion: MOAP-1 is a highly regulated tumor suppressor protein.Significance: The loss of MOAP-1 may significantly contribute to tumorigenesis.
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