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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ther+Adv+Vaccines
2015 ; 3
(4
): 109-20
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Herpes zoster epidemiology, management, and disease and economic burden in
Europe: a multidisciplinary perspective
#MMPMID26478818
Johnson RW
; Alvarez-Pasquin MJ
; Bijl M
; Franco E
; Gaillat J
; Clara JG
; Labetoulle M
; Michel JP
; Naldi L
; Sanmarti LS
; Weinke T
Ther Adv Vaccines
2015[Jul]; 3
(4
): 109-20
PMID26478818
show ga
Herpes zoster (HZ) is primarily a disease of nerve tissue but the acute and
longer-term manifestations require multidisciplinary knowledge and involvement in
their management. Complications may be dermatological (e.g. secondary bacterial
infection), neurological (e.g. long-term pain, segmental paresis, stroke),
ophthalmological (e.g. keratitis, iridocyclitis, secondary glaucoma) or visceral
(e.g. pneumonia, hepatitis). The age-related increased incidence of HZ and its
complications is thought to be a result of the decline in cell-mediated immunity
(immunosenescence), higher incidence of comorbidities with age and
social-environmental changes. Individuals who are immunocompromised as a result
of disease or therapy are also at increased risk, independent of age. HZ and its
complications (particularly postherpetic neuralgia) create a significant burden
for the patient, carers, healthcare systems and employers. Prevention and
treatment of HZ complications remain a therapeutic challenge despite recent
advances. This is an overview of the multidisciplinary implications and
management of HZ in which the potential contribution of vaccination to reducing
the incidence HZ and its complications are also discussed.